PDF(Pubmed)
Abstract：
UNASSIGNED: Seborrheic keratosis (SK) are benign lesions with cosmetic concerns. Role of TCA and erbium YAG laser has already been described individually in the literature. However, there is a scarcity of data on the comparative evaluation of these two modalities in SK.
UNASSIGNED: The aim of this study was to compare the efficacy and safety profile of Erbium YAG laser ablation with 70% TCA for the treatment of facial SK.
UNASSIGNED: A total of 50 cases of facial SK were included in the study. Group A included SK lesions on the right side of face treated with Erbium YAG laser ablation while Group B included SK lesions on the left side of face treated with topical 70% trichloroacetic acid. Repeated sessions of laser and TCA application were given at 2-week intervals till cure was achieved or up to a maximum of three sessions. Grading of response to treatment was assessed as complete response (100% clearance), partial response (>50 to 99% improvement), and inadequate or no response (<50% improvement).
UNASSIGNED: Complete clearance was observed in 40 (80%) and 29 (58%) cases in Groups A and B, respectively. There was a statistically significant difference in clearance rates between the two groups (P = 0.019). Number of sessions was significantly lesser in laser group (mean ± SD = 1.24 ± 0.43) than in the 70% TCA group (mean ± SD = 1.88 ± 0.79) (P = 0.001). Statistically significant lesser downtime was observed in group A (P = 0.001). Patient satisfaction rate was much higher in group A. Hyperpigmentation was more common in group B (TCA).
UNASSIGNED: Although both the treatment modalities achieved good results, erbium YAG laser ablation showed superior results than 70% TCA with better patient satisfaction rates but more downtime. Also, no major adverse effects were observed in the two groups.
UNASSIGNED: The aim of this study was to compare the efficacy and safety profile of Erbium YAG laser ablation with 70% TCA for the treatment of facial SK.
UNASSIGNED: A total of 50 cases of facial SK were included in the study. Group A included SK lesions on the right side of face treated with Erbium YAG laser ablation while Group B included SK lesions on the left side of face treated with topical 70% trichloroacetic acid. Repeated sessions of laser and TCA application were given at 2-week intervals till cure was achieved or up to a maximum of three sessions. Grading of response to treatment was assessed as complete response (100% clearance), partial response (>50 to 99% improvement), and inadequate or no response (<50% improvement).
UNASSIGNED: Complete clearance was observed in 40 (80%) and 29 (58%) cases in Groups A and B, respectively. There was a statistically significant difference in clearance rates between the two groups (P = 0.019). Number of sessions was significantly lesser in laser group (mean ± SD = 1.24 ± 0.43) than in the 70% TCA group (mean ± SD = 1.88 ± 0.79) (P = 0.001). Statistically significant lesser downtime was observed in group A (P = 0.001). Patient satisfaction rate was much higher in group A. Hyperpigmentation was more common in group B (TCA).
UNASSIGNED: Although both the treatment modalities achieved good results, erbium YAG laser ablation showed superior results than 70% TCA with better patient satisfaction rates but more downtime. Also, no major adverse effects were observed in the two groups.
摘要：
■脂溢性角化病（SK）是良性病变，有美容问题。文献中已经单独描述了TCA和铒YAG激光器的作用。然而,SK缺乏这两种模式的比较评估数据。
■这项研究的目的是比较ErbiumYAG激光消融与70％TCA治疗面部SK的疗效和安全性。
■共50例面部SK被纳入研究。A组包括用铒YAG激光消融治疗的面部右侧的SK病变，而B组包括用局部70%三氯乙酸治疗的面部左侧的SK病变。以2周的间隔重复进行激光和TCA应用，直到达到治愈或最多三个疗程。对治疗反应的分级被评估为完全反应(100%清除)。部分响应（>50至99％的改善），和不足或没有反应（<50％的改善）。
■在A组和B组中有40例（80％）和29例（58％）完全清除，分别。两组的清除率差异有统计学意义（P=0.019）。激光组的会议次数（平均值±SD=1.24±0.43）明显少于70％TCA组（平均值±SD=1.88±0.79）（P=0.001）。在A组中观察到有统计学意义的较少的停机时间(P=0.001)。A组患者满意率明显高于B组(TCA)患者的满意度。
■尽管两种治疗方式都取得了良好的效果，与70％TCA相比，铒YAG激光消融效果更好，患者满意度更高，但停机时间更长。此外，两组均未出现重大不良反应.
■这项研究的目的是比较ErbiumYAG激光消融与70％TCA治疗面部SK的疗效和安全性。
■共50例面部SK被纳入研究。A组包括用铒YAG激光消融治疗的面部右侧的SK病变，而B组包括用局部70%三氯乙酸治疗的面部左侧的SK病变。以2周的间隔重复进行激光和TCA应用，直到达到治愈或最多三个疗程。对治疗反应的分级被评估为完全反应(100%清除)。部分响应（>50至99％的改善），和不足或没有反应（<50％的改善）。
■在A组和B组中有40例（80％）和29例（58％）完全清除，分别。两组的清除率差异有统计学意义（P=0.019）。激光组的会议次数（平均值±SD=1.24±0.43）明显少于70％TCA组（平均值±SD=1.88±0.79）（P=0.001）。在A组中观察到有统计学意义的较少的停机时间(P=0.001)。A组患者满意率明显高于B组(TCA)患者的满意度。
■尽管两种治疗方式都取得了良好的效果，与70％TCA相比，铒YAG激光消融效果更好，患者满意度更高，但停机时间更长。此外，两组均未出现重大不良反应.
