PDF(Pubmed)
Abstract：
The detection of circulating tumor DNA (ctDNA) in the plasma of cancer patients is emerging as a very sensitive and specific prognostic biomarker. Previous studies with ctDNA have focused on the ability of ctDNA detection to predict micrometastatic and eventual clinical metastatic relapse. There are few data on the role of ctDNA in monitoring response to local therapy. The present study reports the case of a patient with early-stage lobular breast cancer, with a detectable ctDNA test which resolved with local radiotherapy to the breast. This case suggests that ctDNA is sensitive enough to detect the response of minimal residual disease, localized in the breast, to radiation therapy, and thus may assist in providing indications for local breast cancer treatment.
摘要：
癌症患者血浆中循环肿瘤DNA（ctDNA）的检测正在成为一种非常敏感和特异的预后生物标志物。以前对ctDNA的研究集中在ctDNA检测预测微转移和最终临床转移复发的能力上。关于ctDNA在监测对局部治疗的反应中的作用的数据很少。本研究报告了一名早期小叶乳腺癌患者的病例，用可检测的ctDNA测试，通过对乳房进行局部放射治疗解决。这种情况表明ctDNA足够灵敏，可以检测微小残留病的反应，局限在乳房，放射治疗，因此可能有助于为局部乳腺癌治疗提供适应症。
