PDF(Pubmed)
Abstract：
Plants have evolved interconnected regulatory pathways which enable them to respond and adapt to their environments. In plants, stress memory enhances stress tolerance through the molecular retention of prior stressful experiences, fostering rapid and robust responses to subsequent challenges. Mounting evidence suggests a close link between the formation of stress memories and effective future stress responses. However, the mechanism by which environmental stressors trigger stress memory formation is poorly understood. Here, we review the current state of knowledge regarding the RNA-based regulation on stress memory formation in plants and discuss research challenges and future directions. Specifically, we focus on the involvement of microRNAs (miRNAs), small interfering RNAs (siRNAs), long non-coding RNAs (lncRNAs), and alternative splicing (AS) in stress memory formation. miRNAs regulate target genes via post-transcriptional silencing, while siRNAs trigger stress memory formation through RNA-directed DNA methylation (RdDM). lncRNAs guide protein complexes for epigenetic regulation, and AS of pre-mRNAs is crucial to plant stress memory. Unraveling the mechanisms underpinning RNA-mediated stress memory formation not only advances our knowledge of plant biology but also aids in the development of improved stress tolerance in crops, enhancing crop performance and global food security.
摘要：
植物已经进化出相互关联的调节途径，使它们能够响应和适应环境。在植物中,压力记忆通过先前压力经历的分子保留来增强压力耐受性，促进对后续挑战的快速和强有力的反应。越来越多的证据表明，压力记忆的形成与有效的未来应激反应之间存在密切联系。然而,环境应激源引发应激记忆形成的机制知之甚少。这里,我们回顾了有关基于RNA的植物胁迫记忆形成调控的知识现状，并讨论了研究挑战和未来方向。具体来说,我们专注于微小RNA（miRNA）的参与，小干扰RNA（siRNA），长链非编码RNA（lncRNA），以及应力记忆形成中的选择性剪接(AS)。miRNA通过转录后沉默调节靶基因，而siRNA通过RNA指导的DNA甲基化（RdDM）触发应激记忆形成。lncRNAs指导表观遗传调控的蛋白质复合物，前mRNA的AS对植物胁迫记忆至关重要。解开支撑RNA介导的胁迫记忆形成的机制不仅增进了我们对植物生物学的了解，而且还有助于提高作物的胁迫耐受性，提高作物性能和全球粮食安全。
