Abstract：
Super-resolution molecular probes (SRMPs) are essential tools for visualizing drug dynamics within cells, transcending the resolution limits of conventional microscopy. In this review, we provide an overview of the principles and design strategies of SRMPs, emphasizing their role in accurately tracking drug molecules. By illuminating the intricate processes of drug distribution, diffusion, uptake, and metabolism at a subcellular and molecular level, SRMPs offer crucial insights into therapeutic interventions. Additionally, we explore the practical applications of super-resolution imaging in disease treatment, highlighting the significance of SRMPs in advancing our understanding of drug action. Finally, we discuss future perspectives, envisioning potential advancements and innovations in this field. Overall, this review serves to inform and practitioners about the utility of SRMPs in driving innovation and progress in pharmacology, providing valuable insights for drug development and optimization.
摘要：
超分辨率分子探针（SRMPs）是可视化细胞内药物动力学的重要工具。超越传统显微镜的分辨率极限。在这次审查中,我们概述了SRMP的原则和设计策略，强调它们在准确跟踪药物分子中的作用。通过阐明药物分配的复杂过程，扩散,摄取，亚细胞和分子水平的新陈代谢，SRMP为治疗干预提供了至关重要的见解。此外,我们探索超分辨率成像在疾病治疗中的实际应用，强调SRMP在促进我们对药物作用的理解方面的重要性。最后,我们讨论未来的前景，设想这一领域的潜在进步和创新。总的来说,这篇综述有助于告知和从业者关于SMPs在推动药理学创新和进步方面的效用，为药物开发和优化提供有价值的见解。
