Abstract：
Psoriasis and rosacea are both chronic inflammatory skin disorders resulted from aberrant keratinocyte-immune cell crosstalk, but the common molecular foundations for these 2 conditions are poorly understood. In this study, we reveal that both patients with psoriasis and those with rosacea as well as their mouse models have significantly elevated expressions of SERPINB3/B4 (members of serine protease inhibitor) in the lesional skin. Skin inflammation in mice that resembles both psoriasis and rosacea is prevented by SERPINB3/B4 deficiency. Mechanistically, we demonstrate that SERPINB3/B4 positively induces NF-κB signaling activation, thereby stimulating disease-characteristic inflammatory chemokines and cytokines production in keratinocytes and promoting the chemotaxis of CD4+ T cells. Our results suggest that in keratinocytes, SERPINB3/B4 may be involved in the pathogenesis of both psoriasis and rosacea by stimulating NF-κB signaling, and they indicate a possible treatment overlap between these 2 diseases.
摘要：
银屑病和酒渣鼻都是由异常角质形成细胞-免疫细胞串扰引起的慢性炎症性皮肤病，但是对这两种情况的共同分子基础了解甚少。这里,我们发现牛皮癣和酒渣鼻患者，以及他们的老鼠模型，在病变皮肤中SERPINB3/B4（丝氨酸蛋白酶抑制剂的成员）的表达显着升高。SERPINB3/B4缺乏可预防类似牛皮癣和酒渣鼻的小鼠皮肤炎症。机械上,我们证明SERPINB3/B4正诱导NF-κB信号激活，从而刺激角质形成细胞中疾病特征的炎症趋化因子和细胞因子的产生，并促进CD4+T细胞的趋化性。我们的研究结果表明,在角质形成细胞中，SERPINB3/B4可能通过刺激NF-κB信号参与银屑病和酒渣鼻的发病机制，它们表明这两种疾病之间可能的治疗重叠。
