Abstract：
Tumor microenvironment (TME), is characterized by a complex and heterogenous composition involving a substantial population of immune cells. Myeloid cells comprising over half of the solid tumor mass, are undoubtedly one of the most prominent cell populations associated with tumors. Studies have unambiguously established that myeloid cells play a key role in tumor development, including immune suppression, pro-inflammation, promote tumor metastasis and angiogenesis, for example, tumor-associated macrophages promote tumor progression in a variety of common tumors, including lung cancer, through direct or indirect interactions with the TME. However, due to previous technological constraints, research on myeloid cells often tended to be conducted as studies with low throughput and limited resolution. For example, the conventional categorization of macrophages into M1-like and M2-like subsets based solely on their anti-tumor and pro-tumor roles has disregarded their continuum of states, resulting in an inadequate analysis of the high heterogeneity characterizing myeloid cells. The widespread adoption of single-cell RNA sequencing (scRNA-seq) in tumor immunology has propelled researchers into a new realm of understanding, leading to the establishment of novel subsets and targets. In this review, the origin of myeloid cells in high-incidence cancers, the functions of myeloid cell subsets examined through traditional and single-cell perspectives, as well as specific targeting strategies, are comprehensively outlined. As a result of this endeavor, we will gain a better understanding of myeloid cell heterogeneity, as well as contribute to the development of new therapeutic approaches.
摘要：
肿瘤微环境(TME),其特征在于涉及大量免疫细胞群体的复杂和异质组合物。髓样细胞占实体瘤质量的一半以上，无疑是与肿瘤相关的最突出的细胞群之一。研究明确表明，骨髓细胞在肿瘤发展中起着关键作用。包括免疫抑制,促炎症，促进肿瘤转移和血管生成，例如,肿瘤相关巨噬细胞促进多种常见肿瘤的肿瘤进展，包括肺癌,通过与TME的直接或间接相互作用。然而,由于以前的技术限制，关于骨髓细胞的研究通常倾向于作为低通量和有限分辨率的研究进行。例如,仅仅基于它们的抗肿瘤和促肿瘤作用将巨噬细胞常规分类为M1样和M2样亚群，忽视了它们的连续状态，导致对髓样细胞的高异质性特征的分析不足。单细胞RNA测序（scRNA-seq）在肿瘤免疫学中的广泛应用推动了研究人员进入一个新的认识领域，导致新的子集和目标的建立。在这次审查中,骨髓细胞在高发癌症中的起源，通过传统和单细胞观点检查的骨髓细胞亚群的功能，以及具体的目标策略，全面概述。由于这一努力，我们将更好地了解骨髓细胞的异质性，以及有助于开发新的治疗方法。
