PDF(Pubmed)
Abstract：
Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives.
摘要：
虽然聚集试验的发展显著提高了朊病毒疾病临床诊断的准确性,生物标志物的研究仍然至关重要。要克服的主要挑战是非侵入性采样和探索可以预测发病或反映疾病进展的新生物标志物。这将在不久的将来变得极其重要，当新的治疗方法进行临床评估并最终可用于治疗时。本文旨在概述生物标志物在人类朊病毒疾病中的研究成果,解决现场未满足的需求，并指出了未来的前景。
