PDF(Pubmed)
Abstract：
Bloodstream infection is a major public health concern associated with high mortality and high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention, diagnosis, and management have been recognized as a global health priority by the World Health Organization. Additionally, infection control is increasingly threatened by antimicrobial resistance, which is the focus of global action plans in the framework of a One Health response. In-depth knowledge of the infection process is needed to develop efficient preventive and therapeutic measures. The pathogenesis of bloodstream infection is a dynamic process resulting from the invasion of the vascular system by bacteria, which finely regulate their metabolic pathways and virulence factors to overcome the blood immune defenses and proliferate. In this review, we highlight our current understanding of determinants of bacterial survival and proliferation in the bloodstream and discuss their interactions with the molecular and cellular components of blood.
摘要：
血流感染是全球范围内与高死亡率和高医疗保健成本相关的主要公共卫生问题。菌血症可以引发致命的败血症，其预防，诊断和管理已被世界卫生组织确认为全球卫生优先事项。此外,感染控制越来越受到抗菌素耐药性的威胁，这是“一个健康”框架内全球行动计划的重点。需要对感染过程有深入的了解，以制定有效的预防和治疗措施。血流感染的发病机制是细菌侵入血管系统的动态过程,精细调节其代谢途径和毒力因子，以克服血液免疫防御和增殖。在这次审查中,我们强调了我们目前对血液中细菌存活和增殖的决定因素的理解，并讨论了它们与血液分子和细胞成分的相互作用。
