PDF(Pubmed)
Abstract：
The pathogenesis of major depressive disorder (MDD) involves lipid metabolism. Our earlier research also revealed that MDD patients had much lower total cholesterol (TC) concentrations than healthy controls (HCs). However, it is still unclear why TC decreased in MDD. Here, based on the Ingenuity Knowledge Base\'s ingenuity pathway analysis, we found that sodium voltage-gated channel alpha subunit 11A (SCN11A) might serve as a link between low lipid levels and MDD. We analyzed the TC levels and used ELISA kits to measure the levels of SCN11A in the serum from 139 MDD patients, and 65 HCs to confirm this theory and explore the potential involvement of SCN11A in MDD. The findings revealed that TC levels were considerably lower and SCN11A levels were remarkably increased in MDD patients than those in HCs, while they were significantly reversed in drug-treatment MDD patients than in drug-naïve MDD patients. There was no significant difference in SCN11A levels among MDD patients who used single or multiple antidepressants, and selective serotonin reuptake inhibitors or other antidepressants. Pearson correlation analysis showed that the levels of TC and SCN11A were linked with the Hamilton Depression Rating Scales score. A substantial association was also found between TC and SCN11A. Moreover, a discriminative model made up of SCN11A was discovered, which produced an area under a curve of 0.9571 in the training set and 0.9357 in the testing set. Taken together, our findings indicated that SCN11A may serve as a link between low lipid levels and MDD, and showed promise as a candidate biomarker for MDD.
摘要：
抑郁症（MDD）的发病机制涉及脂质代谢。我们早期的研究还表明，MDD患者的总胆固醇（TC）浓度远低于健康对照（HCs）。然而,目前尚不清楚为什么MDD中TC降低。这里,基于独创性知识库的独创性途径分析，我们发现钠电压门控通道α亚基11A(SCN11A)可能是低脂水平与MDD之间的联系.我们分析了TC水平，并使用ELISA试剂盒测量了139例MDD患者血清中SCN11A的水平，和65个HC来证实这一理论，并探索SCN11A在MDD中的潜在参与。结果显示，MDD患者的TC水平明显低于HCs，SCN11A水平显着升高，而药物治疗的MDD患者比药物初治的MDD患者明显逆转。在使用单一或多种抗抑郁药的MDD患者中，SCN11A水平没有显着差异，和选择性5-羟色胺再摄取抑制剂或其他抗抑郁药。Pearson相关分析显示，TC和SCN11A水平与汉密尔顿抑郁量表评分相关。在TC和SCN11A之间也发现了实质性的关联。此外，发现了由SCN11A组成的判别模型，这在训练集中的曲线下产生了0.9571的面积，在测试集中产生了0.9357的面积。一起来看,我们的研究结果表明，SCN11A可能是低脂水平与MDD之间的联系，并有望成为MDD的候选生物标志物。
