Abstract：
Quantum dots (QDs) are semiconductor nanocrystals (2-10 nm) with unique optical and electronic properties due to quantum confinement effects. They offer high photostability, narrow emission spectra, broad absorption spectrum, and high quantum yields, making them versatile in various applications. Due to their highly reactive surfaces, QDs can conjugate with biomolecules while being used, produced, or unintentionally released into the environment. This systematic review delves into intricate relationship between QDs and proteins, examining their interactions that influence their physicochemical properties, enzymatic activity, ligand binding affinity, and stability. The research utilized electronic databases like PubMed, WOS, and Proquest, along with manual reviews from 2013 to 2023 using relevant keywords, to identify suitable literature. After screening titles and abstracts, only articles meeting inclusion criteria were selected for full text readings. This systematic review of 395 articles identifies 125 articles meeting the inclusion criteria, categorized into five overarching themes, encompassing various mechanisms of QDs and proteins interactions, including adsorption to covalent binding, contingent on physicochemical properties of QDs. Through a meticulous analysis of existing literature, it unravels intricate nature of interaction, significant influence on nanomaterials and biological entities, and potential for synergistic applications harnessing both specific and nonspecific interactions across various fields.
摘要：
量子点(QD)是由于量子限制效应而具有独特的光学和电子性质的半导体纳米晶体(2-10nm)。他们提供高的光稳定性，窄发射光谱，宽吸收光谱，和高量子产率，使他们在各种应用程序多才多艺。由于它们的高活性表面，量子点在使用时可以与生物分子缀合，produced,或者无意中释放到环境中。这篇系统综述深入探讨了量子点和蛋白质之间的复杂关系，检查它们的相互作用，影响它们的物理化学性质，酶活性，配体结合亲和力，和稳定性。这项研究利用了像PubMed这样的电子数据库，WOS,和Proquest,以及2013年至2023年使用相关关键字的手动评论，找出合适的文献。筛选标题和摘要后，仅选择符合纳入标准的文章进行全文阅读.这项对395篇文章的系统审查确定了125篇符合纳入标准的文章，分为五个总体主题，涵盖量子点和蛋白质相互作用的各种机制，包括吸附到共价结合，取决于量子点的物理化学性质。通过对现有文献的细致分析,它揭示了互动的错综复杂的本质，对纳米材料和生物实体的重大影响，以及在各个领域利用特定和非特定相互作用的协同应用的潜力。
