Abstract：
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease, which is characterized by the selective loss of the upper and lower motor neurons. The pathogenesis of ALS remains to be elucidated and has been connected to genetic, environmental and immune conditions. Evidence from clinical and experimental studies has suggested that the immune system played an important role in ALS pathophysiology. Autoantibodies are essential components of the immune system. Several autoantibodies directed at antigens associated with ALS pathogenesis have been identified in the serum and/or cerebrospinal fluid of ALS patients. The aim of this review is to summarize the presence and clinical significance of autoantibodies in ALS.
摘要：
肌萎缩侧索硬化症（ALS）是一种使人衰弱且快速致命的神经退行性疾病，其特征是上部和下部运动神经元的选择性丧失。ALS的发病机制仍有待阐明，并且已经与遗传有关，环境和免疫条件。来自临床和实验研究的证据表明，免疫系统在ALS病理生理学中起着重要作用。自身抗体是免疫系统的重要组成部分。已经在ALS患者的血清和/或脑脊液中鉴定了针对与ALS发病机理相关的抗原的几种自身抗体。这篇综述的目的是总结自身抗体在ALS中的存在和临床意义。
