Abstract：
OBJECTIVE: The aim of this study was to identify prognostic variables at baseline associated with being responding favorably to multidisciplinary rehabilitation in patients with chronic low back pain (CLBP).
METHODS: A responder analysis was conducted based on data from a randomized controlled trial with 26-week follow-up including 165 patients with CLBP treated at a Danish multidisciplinary rehabilitation center. Patients were dichotomized into responders and non-responders based on the outcome of a minimal clinically important difference of six points on the Oswestry Disability Index. The associations between prognostic variables and responders were analyzed using logistic regression.
RESULTS: A total of 139 patients completed the study, of which 42% were classified as responders. Sex and employment status were statistically significant, with a decreased odds ratio (OR) of being a responder found for males compared to females (OR = 0.09, 95% CI = 0.02-0.48) and for being on temporary or permanent social benefits (OR = 0.28, 95% CI = 0.10-0.75) compared to being self-supporting or receiving retirement benefits. Statistically significant interaction (OR = 8.84, 95% CI = 1.11-70.12) was found between males and being on temporary or permanent social benefits.
CONCLUSIONS: In patients with CLBP, female patients as well as patients who were self-supporting or receiving retirement benefits were significantly more likely than male patients or patients on temporary or permanent social benefits to be a responder to multidisciplinary rehabilitation.
METHODS: A responder analysis was conducted based on data from a randomized controlled trial with 26-week follow-up including 165 patients with CLBP treated at a Danish multidisciplinary rehabilitation center. Patients were dichotomized into responders and non-responders based on the outcome of a minimal clinically important difference of six points on the Oswestry Disability Index. The associations between prognostic variables and responders were analyzed using logistic regression.
RESULTS: A total of 139 patients completed the study, of which 42% were classified as responders. Sex and employment status were statistically significant, with a decreased odds ratio (OR) of being a responder found for males compared to females (OR = 0.09, 95% CI = 0.02-0.48) and for being on temporary or permanent social benefits (OR = 0.28, 95% CI = 0.10-0.75) compared to being self-supporting or receiving retirement benefits. Statistically significant interaction (OR = 8.84, 95% CI = 1.11-70.12) was found between males and being on temporary or permanent social benefits.
CONCLUSIONS: In patients with CLBP, female patients as well as patients who were self-supporting or receiving retirement benefits were significantly more likely than male patients or patients on temporary or permanent social benefits to be a responder to multidisciplinary rehabilitation.
摘要：
目的：本研究的目的是确定与对慢性下腰痛（CLBP）患者的多学科康复反应良好相关的基线预后变量。
方法：根据一项为期26周随访的随机对照试验数据，包括在丹麦多学科康复中心接受治疗的165例CLBP患者，进行了响应者分析。根据Oswestry残疾指数上六个点的最小临床重要差异的结果，将患者分为响应者和非响应者。使用逻辑回归分析预后变量与反应者之间的关联。
结果：共有139名患者完成了研究，其中42%被归类为响应者。性别和就业状况有统计学意义,男性与女性相比(OR=0.09,95%CI=0.02-0.48)和暂时或永久社会福利(OR=0.28,95%CI=0.10-0.75)的应答者比值比(OR)降低。在男性之间发现了具有统计学意义的相互作用（OR=8.84，95％CI=1.11-70.12），并且具有暂时或永久的社会效益。
结论：在CLBP患者中，与男性患者或有临时或永久社会福利的患者相比,女性患者以及自立或领取退休福利的患者更有可能接受多学科康复治疗.
方法：根据一项为期26周随访的随机对照试验数据，包括在丹麦多学科康复中心接受治疗的165例CLBP患者，进行了响应者分析。根据Oswestry残疾指数上六个点的最小临床重要差异的结果，将患者分为响应者和非响应者。使用逻辑回归分析预后变量与反应者之间的关联。
结果：共有139名患者完成了研究，其中42%被归类为响应者。性别和就业状况有统计学意义,男性与女性相比(OR=0.09,95%CI=0.02-0.48)和暂时或永久社会福利(OR=0.28,95%CI=0.10-0.75)的应答者比值比(OR)降低。在男性之间发现了具有统计学意义的相互作用（OR=8.84，95％CI=1.11-70.12），并且具有暂时或永久的社会效益。
结论：在CLBP患者中，与男性患者或有临时或永久社会福利的患者相比,女性患者以及自立或领取退休福利的患者更有可能接受多学科康复治疗.
