PDF(Pubmed)
Abstract：
Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular diseases (CVDs) that has become a global public health problem. Puerarin (PUE), the principal active compound of Pueraria lobata, has the effects of regulating glucose and lipid metabolism and protecting against cardiovascular damage. This study aimed to investigate whether dietary supplementation with PUE could ameliorate MetS and its associated cardiovascular damage. Rats were randomly divided into three groups: the normal diet group (NC), the high-fat/high-sucrose diet group (HFHS), and the HFHS plus PUE diet group (HFHS-PUE). The results showed that PUE-supplemented rats exhibited enhanced glucose tolerance, improved lipid parameters, and reduced blood pressure compared to those on the HFHS diet alone. Additionally, PUE reversed the HFHS-induced elevations in the atherogenic index (AI) and the activities of serum lactate dehydrogenase (LDH) and creatine kinase (CK). Ultrasonic evaluations indicated that PUE significantly ameliorated cardiac dysfunction and arterial stiffness. Histopathological assessments further confirmed that PUE significantly mitigated cardiac remodeling, arterial remodeling, and neuronal damage in the brain. Moreover, PUE lowered systemic inflammatory indices including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune-inflammation index (SII). In conclusion, dietary supplementation with PUE effectively moderated metabolic disorders, attenuated systemic inflammation, and minimized cardiovascular damage in rats with MetS induced by an HFHS diet. These results provide novel insights into the potential benefits of dietary PUE supplementation for the prevention and management of MetS and its related CVDs.
摘要：
代谢综合征（MetS）是心血管疾病（CVD）的一组危险因素，已成为全球公共卫生问题。葛根素(PUE),葛根的主要活性化合物，具有调节糖脂代谢和防止心血管损害的作用。这项研究旨在调查膳食补充PUE是否可以改善MetS及其相关的心血管损害。大鼠随机分为三组:正常饮食组(NC),高脂肪/高糖饮食组（HFHS），和HFHS加PUE饮食组（HFHS-PUE）。结果表明，补充PUE的大鼠表现出增强的糖耐量，改善脂质参数，与单独使用HFHS饮食的人相比，血压降低。此外,PUE逆转了HFHS诱导的动脉粥样硬化指数（AI）以及血清乳酸脱氢酶（LDH）和肌酸激酶（CK）活性的升高。超声评估表明PUE显着改善了心功能不全和动脉僵硬度。组织病理学评估进一步证实，PUE可显着减轻心脏重塑，动脉重塑,和大脑中的神经元损伤。此外，PUE降低全身炎症指标，包括C反应蛋白（CRP），中性粒细胞与淋巴细胞比率（NLR），单核细胞与淋巴细胞比率（MLR），和全身免疫炎症指数（SII）。总之,膳食补充PUE可有效缓解代谢紊乱，减轻全身性炎症，最大限度地减少了HFHS饮食诱导的MetS大鼠的心血管损伤。这些结果为膳食PUE补充对预防和管理MetS及其相关CVD的潜在益处提供了新的见解。
