METHODS: A systematic literature search concerning COPD was performed in electronic databases (PUBMED, UpToDate, Google Scholar, ResearchGate), supplemented with manual research. We searched in these databases for articles published until March 2024. The following search words were searched in the databases in all possible combinations: chronic obstructive pulmonary disease (COPD), endothelial damage, vascular impairment, functional evaluation, capillaroscopy, video capillaroscopy, nailfold video capillaroscopy. Only manuscripts written in English were considered for this review. Papers were included only if they were able to define a relationship between COPD and endothelium dysfunction.
RESULTS: The search selected 10 articles, and among these, only three previous reviews were available. Retinal vessel imaging, flow-mediated dilation (FMD), and skin autofluorescence (AF) are reported as the most valuable methods for assessing endothelial dysfunction in COPD patients.
CONCLUSIONS: It has been assumed that decreased nitric oxide (NO) levels leads to microvascular damage in COPD patients. This finding allows us to assume NVC\'s potential effectiveness in COPD patients. However, this potential link is based on assumption; further investigations are needed to confirm this hypothesis.
方法:在电子数据库中进行了有关COPD的系统文献检索(PUBMED,UpToDate,谷歌学者,ResearchGate),辅以手工研究。我们在这些数据库中搜索了直到2024年3月发表的文章。在数据库中以所有可能的组合搜索以下搜索词:慢性阻塞性肺疾病(COPD),内皮损伤,血管损伤,功能评估,毛细血管镜检查,视频毛细管镜检查,甲折视频毛细管镜检查。这篇评论只考虑了用英语写的手稿。仅在能够定义COPD与内皮功能障碍之间的关系时,才包括论文。
结果:搜索选择了10篇文章,其中,只有三个以前的评论可用。视网膜血管成像,流动介导的扩张(FMD),据报道,皮肤自发荧光(AF)是评估COPD患者内皮功能障碍的最有价值的方法。
结论:据推测,一氧化氮(NO)水平降低会导致COPD患者的微血管损伤。这一发现使我们能够假设NVC在COPD患者中的潜在有效性。然而,这种潜在的联系是基于假设;需要进一步的调查来证实这一假设.