PDF(Pubmed)
Abstract：
Human granulocyte colony-stimulating factor (G-CSF) is a granulopoietic growth factor used in the treatment of neutropenia following chemotherapy, myeloablative treatment, or healthy donors preparing for allogeneic transplantation. Few hypersensitivity reactions (HRs) have been reported, and its true prevalence is unknown. We aimed to systematically characterize G-CSF-induced HRs while including a comprehensive list of adverse reactions. We reviewed articles published before January 2024 by searching in the PubMed, Embase, Cochrane Library, and Web of Science databases using a combination of the keywords listed, selected the ones needed, and extracted relevant data. The search resulted in 68 entries, 17 relevant to our study and 7 others found from manually searching bibliographic sources. A total of 40 cases of G-CSF-induced HR were described and classified as immediate (29) or delayed (11). Immediate ones were mostly caused by filgrastim (13 minimum), with at least 9 being grade 5 on the WAO anaphylaxis scale. Delayed reactions were mostly maculopapular exanthemas and allowed for the continuation of G-CSF. Reactions after first exposure frequently appeared and were present in at least 11 of the 40 cases. Only five desensitization protocols have been found concerning the topic at hand in the analyzed data. We believe this study brings to light the research interest in this topic that could benefit from further exploration, and propose regular updating to include the most recently published evidence.
摘要：
人粒细胞集落刺激因子（G-CSF）是一种用于治疗化疗后中性粒细胞减少症的粒细胞生长因子，清髓性治疗,或准备同种异体移植的健康供体。很少有过敏反应（HRs）的报道，其真正的流行率是未知的。我们旨在系统地表征G-CSF诱导的HR，同时包括全面的不良反应列表。我们通过在PubMed中搜索来审查2024年1月之前发表的文章，Embase,科克伦图书馆,和WebofScience数据库使用列出的关键字的组合，选择了需要的，并提取相关数据。搜索结果有68个条目，与我们的研究相关的17个，以及从手动搜索书目来源中发现的其他7个。总共描述了40例G-CSF诱导的HR，并分为立即（29）或延迟（11）。近期主要是由非格司亭(最少13例)引起的，在WAO过敏反应量表上至少有9人是5级。延迟反应主要是斑丘疹性皮疹，并允许G-CSF继续。首次暴露后的反应经常出现，并且在40例中的至少11例中存在。在分析的数据中，仅发现了五种脱敏方案。我们相信这项研究揭示了该主题的研究兴趣，可以从进一步的探索中受益，并建议定期更新，以包括最近发布的证据。
