PDF(Pubmed)
Abstract：
To date, several members of the transient receptor potential (TRP) channels which provide a wide array of roles have been found in the gastrointestinal tract (GI). The goal of earlier research was to comprehend the intricate signaling cascades that contribute to TRP channel activation as well as how these receptors\' activity affects other systems. Moreover, there is a large volume of published studies describing the role of TRP channels in a number of pathological disorders, including inflammatory bowel disease (IBD) and sepsis. Nevertheless, the generalizability of these results is subject to certain limitations. For instance, the study of IBD relies on various animal models and experimental methods, which are unable to precisely imitate the multifactorial chronic disease. The diverse pathophysiological mechanisms and unique susceptibility of animals may account for the inconsistency of the experimental data collected. The main purpose of this study was to conduct a comprehensive review and analysis of existing studies on transient receptor potential (TRP) channels implicating specific models of colitis and sepsis, with particular emphasis on their involvement in pathological disorders such as IBD and sepsis. Furthermore, the text endeavors to evaluate the generalizability of experimental findings, taking into consideration the limitations posed by animal models and experimental methodologies. Finally, we also provide an updated schematic of the most important and possible molecular signaling pathways associated with TRP channels in IBD and sepsis.
摘要：
迄今为止,在胃肠道（GI）中发现了几种瞬时受体电位（TRP）通道，它们具有广泛的作用。早期研究的目标是理解有助于TRP通道激活的复杂信号级联，以及这些受体的活性如何影响其他系统。此外，有大量已发表的研究描述了TRP通道在许多病理疾病中的作用，包括炎症性肠病（IBD）和败血症。然而，这些结果的概括性受到某些限制。例如,IBD的研究依赖于各种动物模型和实验方法，无法精确模仿多因素慢性疾病。动物的多种病理生理机制和独特的易感性可能是收集的实验数据不一致的原因。这项研究的主要目的是对涉及结肠炎和败血症特定模型的瞬时受体电位（TRP）通道的现有研究进行全面回顾和分析。特别强调它们参与病理性疾病，如IBD和脓毒症。此外，本文努力评估实验结果的普遍性，考虑到动物模型和实验方法的局限性。最后,我们还提供了IBD和脓毒症中与TRP通道相关的最重要和可能的分子信号通路的最新示意图.
