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Abstract：
We aimed to analyze the association between CYP7B1 and prostate cancer, along with its association with proteins involved in cancer and metabolic processes. A retrospective analysis was performed on 390 patients with prostate cancer (PC) or benign prostatic hyperplasia (BPH). We investigated the interactions between CYP7B1 expression and proteins associated with PC and metabolic processes, followed by an analysis of the risk of biochemical recurrence based on CYP7B1 expression. Of the 139 patients with elevated CYP7B1 expression, 92.8% had prostate cancer. Overall, no increased risk of biochemical recurrence was associated with CYP7B1 expression. However, in a non-diabetic subgroup analysis, higher CYP7B1 expression indicated a higher risk of biochemical recurrence, with an HR of 1.78 (CI: 1.0-3.2, p = 0.05). PC is associated with elevated CYP7B1 expression. In a subgroup analysis of non-diabetic patients, elevated CYP7B1 expression was associated with an increased risk of biochemical recurrence, suggesting increased cancer aggressiveness.
摘要：
我们旨在分析CYP7B1与前列腺癌之间的关系，以及它与癌症和代谢过程中涉及的蛋白质的关联。对390例前列腺癌(PC)或良性前列腺增生(BPH)患者进行回顾性分析。我们研究了CYP7B1表达与PC和代谢过程相关蛋白之间的相互作用，然后根据CYP7B1表达分析生化复发的风险。139例CYP7B1表达升高的患者中,92.8%患有前列腺癌。总的来说,生化复发风险无增加与CYP7B1表达相关.然而,在非糖尿病亚组分析中，较高的CYP7B1表达表明生化复发的风险较高，HR为1.78（CI：1.0-3.2，p=0.05）。PC与CYP7B1表达升高相关。在非糖尿病患者的亚组分析中，CYP7B1表达升高与生化复发风险增加相关,表明癌症侵袭性增加。
