PDF(Pubmed)
Abstract：
This study evaluated the efficacy and safety of two anesthetic agents, alfaxalone and propofol, on maternal physiological parameters (heart and respiratory rates, blood pressure, and temperature) on either ovariohysterectomies or cesarean sections in bitches. A total of 34 healthy and pyometra-affected females (classified as ASA II), were induced with IV propofol (4 mg/kg), while 35 females, both healthy and pyometra affected, were induced with IV alfaxalone (1 mg/kg). For cesarean sections, females (ASA II) were induced with propofol (n = 14) or alfaxalone (n = 14). Additionally, the neonatal viability and modified Apgar score were recorded at 5, 60, and 120 min post-delivery. There were no significant differences in the physiological parameters when comparing the use of propofol and alfaxalone in bitches undergoing ovariohysterectomies, regardless of their health status, nor when comparing cesarean sections. It was observed that bitches induced with propofol occasionally required an additional dose for maintenance of the anesthesia. Neonatal mortality rates were similar for both groups; however, alfaxalone was associated with higher neonatal viability as indicated by the Apgar scores. The findings suggest that both anesthetic protocols are effective and safe for use in canine reproductive surgeries, with no major differences in basic physiological parameters\' alteration or neonatal outcomes between the two agents.
摘要：
这项研究评估了两种麻醉剂的疗效和安全性，阿法沙酮和异丙酚,关于母体生理参数(心率和呼吸率，血压,和温度）在卵巢子宫切除术或母犬剖宫产术中。共有34名健康和受子宫积脓影响的女性（归类为ASAII），用静脉注射丙泊酚(4mg/kg)诱导，而35名女性，既健康又受子宫积脓影响，用静脉注射阿法沙酮（1mg/kg）诱导。对于剖腹产，女性（ASAII）用丙泊酚（n=14）或阿法沙松（n=14）诱导。此外,在分娩后5,60和120min记录新生儿生存力和改良的Apgar评分.当比较在接受卵巢子宫切除术的母犬中使用异丙酚和阿法沙酮时，生理参数没有显着差异，不管他们的健康状况如何，在比较剖宫产时也是如此。观察到用异丙酚诱导的母犬偶尔需要额外的剂量来维持麻醉。两组新生儿死亡率相似；然而，阿法沙酮与较高的新生儿生存能力相关，如阿普加评分所示。研究结果表明，两种麻醉方案都有效且安全地用于犬生殖手术，两种药物在基本生理参数改变或新生儿结局方面没有重大差异。
