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Abstract：
Background/Objectives: To investigate changes in visual acuity and retinal sensitivity and thickness after intravitreal ranibizumab injection (IRI) for macular edema in branch retinal vein occlusion (BRVO) patients. Methods: This study evaluated 34 patients with treatment-naïve BRVO and at least 6 months\' follow-up after pro re nata IRI. Best-corrected visual acuity (BCVA) was determined as the logarithm of the minimum angle of resolution (logMAR). In nine retinal regions, retinal sensitivity was calculated by MP-3 microperimetry; and in nine macular subfields, retinal thickness was measured by optical coherence tomography (OCT); evaluations were performed before IRI and then monthly for 6 months. Results: IRI significantly improved visual acuity and retinal sensitivity and thickness. In patients with good improvement in BCVA (change in logMAR > 0.2), IRI significantly improved retinal sensitivity in eight of nine regions, i.e., in all except the outer non-occluded region, and in patients with poor improvement in BCVA (change in logMAR < 0.2), in six of nine regions, i.e., not in the inner, outer non-occluded, and outer temporal regions. We found significant differences in the trend profile in the foveal, outer occluded, and inner nasal regions between patients with good and poor improvement in BCVA. Conclusions: The findings suggest that IRI improves visual acuity and retinal sensitivity and thickness and that retinal effects may vary between patients with good and poor visual improvement.
摘要：
背景/目的:探讨玻璃体腔注射雷珠单抗(IRI)治疗视网膜分支静脉阻塞(BRVO)黄斑水肿后视力、视网膜敏感度及厚度的变化。方法：这项研究评估了34例接受初治BRVO治疗的患者，并在prorenataIRI后进行了至少6个月的随访。最佳矫正视力（BCVA）确定为最小分辨率角（logMAR）的对数。在九个视网膜区域，通过MP-3显微视野法计算视网膜敏感度；在9个黄斑子场中，通过光学相干断层扫描(OCT)测量视网膜厚度;评估在IRI前进行,然后每月进行一次,为期6个月.结果:IRI显著改善视力、视网膜敏感度和厚度。在BCVA改善良好（logMAR变化>0.2）的患者中，IRI显著改善了9个区域中的8个区域的视网膜敏感度，即，除了外部非遮挡区域之外，BCVA改善不良的患者（logMAR变化<0.2），在九个地区中的六个，即，不是在内心，外部非闭塞，和外部时间区域。我们发现中央凹的趋势特征存在显着差异，外部闭塞，BCVA改善良好和不良的患者之间的鼻内区域。结论：研究结果表明，IRI可以改善视力，视网膜敏感性和厚度，并且视力改善良好和不良的患者对视网膜的影响可能有所不同。
