PDF(Pubmed)
Abstract：
The tumor microenvironment (TME), a complex assembly of cellular and extracellular matrix (ECM) components, plays a crucial role in driving tumor progression, shaping treatment responses, and influencing metastasis. This narrative review focuses on the cutaneous squamous cell carcinoma (cSCC) tumor stroma, highlighting its key constituents and their dynamic contributions. We examine how significant changes within the cSCC ECM-specifically, alterations in fibronectin, hyaluronic acid, laminins, proteoglycans, and collagens-promote cancer progression, metastasis, and drug resistance. The cellular composition of the cSCC TME is also explored, detailing the intricate interplay of cancer-associated fibroblasts (CAFs), mesenchymal stem cells (MSCs), endothelial cells, pericytes, adipocytes, and various immune cell populations. These diverse players modulate tumor development, angiogenesis, and immune responses. Finally, we emphasize the TME\'s potential as a therapeutic target. Emerging strategies discussed in this review include harnessing the immune system (adoptive cell transfer, checkpoint blockade), hindering tumor angiogenesis, disrupting CAF activity, and manipulating ECM components. These approaches underscore the vital role that deciphering TME interactions plays in advancing cSCC therapy. Further research illuminating these complex relationships will uncover new avenues for developing more effective treatments for cSCC.
摘要：
肿瘤微环境（TME），细胞和细胞外基质（ECM）成分的复杂组装，在推动肿瘤进展中起着至关重要的作用，塑造治疗反应，并影响转移。这篇叙述性综述侧重于皮肤鳞状细胞癌（cSCC）肿瘤基质，突出其关键组成部分及其动态贡献。我们检查了cSCCECM内的显著变化，纤连蛋白的改变，透明质酸，层粘连蛋白,蛋白聚糖,和胶原蛋白促进癌症进展，转移,和抗药性。还探索了cSCCTME的细胞组成，详述癌症相关成纤维细胞（CAF）的复杂相互作用，间充质干细胞(MSCs),内皮细胞，周细胞,脂肪细胞,和各种免疫细胞群。这些不同的参与者调节肿瘤的发展，血管生成,和免疫反应。最后,我们强调TME作为治疗靶点的潜力。这篇综述中讨论的新兴策略包括利用免疫系统(过继性细胞转移，检查站封锁)，阻碍肿瘤血管生成，破坏CAF活动,和操纵ECM组件。这些方法强调了破译TME相互作用在推进cSCC治疗中的重要作用。阐明这些复杂关系的进一步研究将为开发更有效的cSCC治疗方法提供新的途径。
