PDF(Pubmed)
Abstract：
In this systematic review and meta-analysis (PRISMA-compliant), we tried to investigate diagnostic and prognostic values of 18F-FDG PET in uveal melanoma. A systematic search was conducted on the main medical literature databases to include studies that evaluated 18F-FDG PET as the imaging modality to evaluate patients with uveal melanoma. Overall, 27 studies were included. Twelve had data about the detection rate of 18F-FDG PET in primary intra-ocular tumours. The pooled sensitivity was 45% (95%CI: 41-50%). Furthermore, studies showed that the larger the primary tumour, the higher its uptake. Among the included studies, 13 assessed 18F-FDG PET in detecting metastasis. The pooled sensitivity and specificity were 96% (95%CI: 81-99%) and 100% (95%CI: 94-100%), respectively. Regarding liver metastasis, they were 95% (95%CI: 79-99%) and 100% (95%CI: 91-100%), respectively. Noteworthy, the level of 18F-FDG uptake was a strong predictor of patient survival. Lastly, 18F-FDG PET could characterise lesions from the histopathology perspective, distinguishing high-risk from low-risk diseases. Overall, although not reliable in detecting primary intra-ocular tumours, 18F-FDG PET is highly accurate for diagnosing metastatic uveal melanomas. It can also be a highly valuable modality in terms of patient prognostication. Thus, 18F-FDG PET can be recommended in patients diagnosed with uveal melanoma to enhance decision-making and patient management.
摘要：
在这篇系统综述和荟萃分析(符合PRISMA标准)中，我们试图探讨18F-FDGPET在葡萄膜黑色素瘤中的诊断和预后价值.对主要医学文献数据库进行了系统搜索，包括评估18F-FDGPET作为评估葡萄膜黑色素瘤患者的成像方式的研究。总的来说,共纳入27项研究。12个有关于原发性眼内肿瘤中18F-FDGPET检出率的数据。合并敏感性为45％（95CI：41-50％）。此外，研究表明，原发性肿瘤越大，它的摄取越高。在纳入的研究中，图13评估了18F-FDGPET在检测转移中的作用。合并的敏感性和特异性分别为96％（95CI：81-99％）和100％（95CI：94-100％），分别。关于肝转移，它们是95%(95CI:79-99%)和100%(95CI:91-100%)，分别。值得注意的是,18F-FDG摄取水平是患者生存的重要预测因子.最后,18F-FDGPET可以从组织病理学角度表征病变，区分高风险和低风险疾病。总的来说,虽然在检测原发性眼内肿瘤方面不可靠，18F-FDGPET对于诊断转移性葡萄膜黑色素瘤非常准确。就患者预后而言，它也可能是非常有价值的模态。因此，18F-FDGPET可推荐用于诊断为葡萄膜黑色素瘤的患者，以增强决策和患者管理。
