PDF(Pubmed)
Abstract：
BACKGROUND: There is a need for a better understanding of survivorship-related issues in advanced cancer survivors treated with immune checkpoint blockade (ICB). The purpose of this study was to identify survivorship-related issues, with a focus on psychological distress, cognitive complaints, physical sequelae, impact on family dynamics, and care needs in unresectable, advanced cancer survivors treated with ICB.
METHODS: Semi-structured interviews and patient-reported outcome measures (PROMs) were conducted in survivors followed up at the University Hospital Brussels. We performed content analysis on the semi-structured interviews and analyzed the PROMs descriptively.
RESULTS: 70 cancer survivors (71.4%) consented to participate between July 2022 and November 2023. Clinical fear of cancer recurrence (FCR) was present in 54.3% of the cancer survivors, and 18.6% had elevated cognitive complaints. We identified triggers related to clinically important psychological distress, such as immune-related adverse events, the progression/recurrence of disease, difficulties in adjusting to life after treatment, and co-existing life stressors, alongside persistent physical issues and unmet psychological and nutritional care needs.
CONCLUSIONS: Our results indicate the existence of persistent psychological, physical, and cognitive issues, and support the need for routine screening for FCR. The identified triggers related to severe psychological distress can aid clinicians in timely referring the patient, thereby enhancing survivorship care.
METHODS: Semi-structured interviews and patient-reported outcome measures (PROMs) were conducted in survivors followed up at the University Hospital Brussels. We performed content analysis on the semi-structured interviews and analyzed the PROMs descriptively.
RESULTS: 70 cancer survivors (71.4%) consented to participate between July 2022 and November 2023. Clinical fear of cancer recurrence (FCR) was present in 54.3% of the cancer survivors, and 18.6% had elevated cognitive complaints. We identified triggers related to clinically important psychological distress, such as immune-related adverse events, the progression/recurrence of disease, difficulties in adjusting to life after treatment, and co-existing life stressors, alongside persistent physical issues and unmet psychological and nutritional care needs.
CONCLUSIONS: Our results indicate the existence of persistent psychological, physical, and cognitive issues, and support the need for routine screening for FCR. The identified triggers related to severe psychological distress can aid clinicians in timely referring the patient, thereby enhancing survivorship care.
摘要：
背景：需要更好地了解接受免疫检查点阻断（ICB）治疗的晚期癌症幸存者的生存相关问题。这项研究的目的是确定与生存有关的问题，专注于心理困扰，认知抱怨，身体后遗症，对家庭动态的影响，和不可切除的护理需求，ICB治疗晚期癌症幸存者。
方法：在布鲁塞尔大学医院随访的幸存者中进行了半结构化访谈和患者报告的结果测量（PROMs）。我们对半结构化访谈进行了内容分析，并对PROM进行了描述性分析。
结果：70名癌症幸存者（71.4％）同意在2022年7月至2023年11月期间参加。癌症复发（FCR）的临床恐惧存在于54.3％的癌症幸存者中，18.6%的人认知投诉升高。我们确定了与临床上重要的心理困扰有关的触发因素，如免疫相关的不良事件，疾病的进展/复发，治疗后难以适应生活，和共存的生活压力源，除了持续的身体问题和未满足的心理和营养护理需求。
结论：我们的结果表明存在持续的心理，物理，和认知问题，并支持FCR常规筛查的需要。确定的与严重心理困扰相关的触发因素可以帮助临床医生及时转诊患者，从而提高生存护理。
方法：在布鲁塞尔大学医院随访的幸存者中进行了半结构化访谈和患者报告的结果测量（PROMs）。我们对半结构化访谈进行了内容分析，并对PROM进行了描述性分析。
结果：70名癌症幸存者（71.4％）同意在2022年7月至2023年11月期间参加。癌症复发（FCR）的临床恐惧存在于54.3％的癌症幸存者中，18.6%的人认知投诉升高。我们确定了与临床上重要的心理困扰有关的触发因素，如免疫相关的不良事件，疾病的进展/复发，治疗后难以适应生活，和共存的生活压力源，除了持续的身体问题和未满足的心理和营养护理需求。
结论：我们的结果表明存在持续的心理，物理，和认知问题，并支持FCR常规筛查的需要。确定的与严重心理困扰相关的触发因素可以帮助临床医生及时转诊患者，从而提高生存护理。
