Abstract：
Morphogenesis from cells to tissue gives rise to the complex architectures that make our organs. How cells and their dynamic behavior are translated into functional spatial patterns is only starting to be understood. Recent advances in quantitative imaging revealed that, although highly heterogeneous, cellular behaviors make reproducible tissue patterns. Emerging evidence suggests that mechanisms of cellular coordination, intrinsic variability and plasticity are critical for robust pattern formation. While pattern development shows a high level of fidelity, tissue organization has undergone drastic changes throughout the course of evolution. In addition, alterations in cell behavior, if unregulated, can cause developmental malformations that disrupt function. Therefore, comparative studies of different species and of disease models offer a powerful approach for understanding how novel spatial configurations arise from variations in cell behavior and the fundamentals of successful pattern formation. In this chapter, I dive into the development of the vertebrate nervous system to explore efforts to dissect pattern formation beyond molecules, the emerging core principles and open questions.
摘要：
从细胞到组织的形态发生产生了构成我们器官的复杂结构。细胞及其动态行为如何转化为功能空间模式才刚刚开始被理解。定量成像的最新进展表明，尽管高度异质，细胞行为形成可重复的组织模式。新出现的证据表明，细胞协调的机制，内在变异性和可塑性对于稳健的模式形成至关重要。虽然模式开发显示出很高的保真度，组织组织在整个进化过程中经历了巨大的变化。此外,细胞行为的改变，如果不受管制，会导致破坏功能的发育畸形。因此,不同物种和疾病模型的比较研究提供了一种强大的方法来理解新的空间配置是如何从细胞行为的变化和成功模式形成的基础中产生的。在这一章中,我深入研究脊椎动物神经系统的发展，以探索在分子之外解剖模式形成的努力，新兴的核心原则和悬而未决的问题。
