Abstract：
Evidence on the importance of rapid-eye-movement sleep (REMS) in processing emotions is accumulating. The focus of this systematic review is the outcomes of experimental REMS deprivation (REMSD), which is the most common method in animal models and human studies on REMSD. This review revealed that variations in the applied REMSD methods were substantial. Animal models used longer deprivation protocols compared with studies in humans, which mostly reported acute deprivation effects after one night. Studies on animal models showed that REMSD causes aggressive behavior, increased pain sensitivity, reduced sexual behavior, and compromised consolidation of fear memories. Animal models also revealed that REMSD during critical developmental periods elicits lasting consequences on affective-related behavior. The few human studies revealed increases in pain sensitivity and suggest stronger consolidation of emotional memories after REMSD. As pharmacological interventions (such as selective serotonin reuptake inhibitors [SSRIs]) may suppress REMS for long periods, there is a clear gap in knowledge regarding the effects and mechanisms of chronic REMS suppression in humans.
摘要：
关于快速眼动睡眠（REMS）在处理情绪中的重要性的证据正在积累。本系统综述的重点是实验性REMS剥夺(REMSD)的结果，这是REMSD动物模型和人体研究中最常见的方法。这篇综述显示，应用的REMSD方法存在很大差异。与人类研究相比，动物模型使用了更长的剥夺方案，主要报道了一夜后的急性剥夺效应。对动物模型的研究表明，REMSD引起攻击行为，增加疼痛敏感性，减少性行为,以及恐惧记忆的整合。动物模型还显示，在关键发育时期的REMSD会对情感相关行为产生持久的影响。少数人类研究显示疼痛敏感性增加，并表明REMSD后情感记忆的巩固更强。由于药物干预（如选择性5-羟色胺再摄取抑制剂[SSRIs]）可能会长期抑制REMS，关于人类慢性REMS抑制的影响和机制的知识存在明显差距。
