Abstract：
BACKGROUND: Accumulating evidence suggests that latent infection with Toxoplasma gondii (T. gondii) is associated with a variety of neuropsychiatric and behavioral conditions. This research aims to explore the potential correlation between T. gondii antibody positivity and neuropsychiatric disorders through a comprehensive prospective cohort study.
METHODS: The cohort study utilized the UK Biobank database to recruit 8814 individuals with no prior diagnosis of neuropsychiatric disorders. Cox proportional hazards models were employed to investigate the associations between T. gondii P22 antibody seropositivity (P22+) and the development of various types of neuropsychiatric disorders.
RESULTS: Of the population, 14.65 % tested positive for T. gondii P22 antibody. The presence of T. gondii P22 antibody showed a slight inverse association with epilepsy (HR: 0.28; 95 % CI: 0.10-0.77), while it was positively associated with an increased risk of developing anxiety disorders (HR: 1.38; 95 % CI: 1.04-1.83).
CONCLUSIONS: The study sample consisted mostly of white British individuals aged 40 to 69 years old. Although we adjusted for potential confounders, there may be other unmeasured and residual confounding factors that could have influenced our reported associations.
CONCLUSIONS: The findings suggested an increased risk of anxiety and potential evidence of epilepsy associated with T. gondii P22+. However, our analysis did not reveal an increased risk of several other neuropsychiatric conditions including Alzheimer\'s disease, dementia, substance abuse disorders, depression, and neurodegenerative disorders, associated with P22 antibody seropositivity.
METHODS: The cohort study utilized the UK Biobank database to recruit 8814 individuals with no prior diagnosis of neuropsychiatric disorders. Cox proportional hazards models were employed to investigate the associations between T. gondii P22 antibody seropositivity (P22+) and the development of various types of neuropsychiatric disorders.
RESULTS: Of the population, 14.65 % tested positive for T. gondii P22 antibody. The presence of T. gondii P22 antibody showed a slight inverse association with epilepsy (HR: 0.28; 95 % CI: 0.10-0.77), while it was positively associated with an increased risk of developing anxiety disorders (HR: 1.38; 95 % CI: 1.04-1.83).
CONCLUSIONS: The study sample consisted mostly of white British individuals aged 40 to 69 years old. Although we adjusted for potential confounders, there may be other unmeasured and residual confounding factors that could have influenced our reported associations.
CONCLUSIONS: The findings suggested an increased risk of anxiety and potential evidence of epilepsy associated with T. gondii P22+. However, our analysis did not reveal an increased risk of several other neuropsychiatric conditions including Alzheimer\'s disease, dementia, substance abuse disorders, depression, and neurodegenerative disorders, associated with P22 antibody seropositivity.
摘要：
背景：越来越多的证据表明弓形虫潜伏感染与各种神经精神和行为状况有关。本研究旨在通过一项全面的前瞻性队列研究，探讨弓形虫抗体阳性与神经精神疾病之间的潜在相关性。
方法：队列研究利用UKBiobank数据库招募了8814名先前未诊断为神经精神疾病的个体。Cox比例风险模型用于研究弓形虫P22抗体血清阳性（P22）与各种类型的神经精神疾病发展之间的关系。
结果：在人口中，14.65%的弓形虫P22抗体检测呈阳性。弓形虫P22抗体的存在与癫痫有轻微的负相关(HR:0.28;95%CI:0.10-0.77),而与患焦虑症的风险增加呈正相关(HR:1.38;95%CI:1.04-1.83).
结论：研究样本主要由40至69岁的英国白人组成。尽管我们调整了潜在的混杂因素，可能还有其他未测量的和残留的混杂因素可能影响我们报告的关联.
结论：研究结果表明，与弓形虫P22相关的焦虑和癫痫的潜在证据的风险增加。然而,我们的分析并没有揭示其他几种神经精神疾病的风险增加，包括阿尔茨海默病，痴呆症,药物滥用障碍，抑郁症,和神经退行性疾病，与P22抗体血清阳性相关。
方法：队列研究利用UKBiobank数据库招募了8814名先前未诊断为神经精神疾病的个体。Cox比例风险模型用于研究弓形虫P22抗体血清阳性（P22）与各种类型的神经精神疾病发展之间的关系。
结果：在人口中，14.65%的弓形虫P22抗体检测呈阳性。弓形虫P22抗体的存在与癫痫有轻微的负相关(HR:0.28;95%CI:0.10-0.77),而与患焦虑症的风险增加呈正相关(HR:1.38;95%CI:1.04-1.83).
结论：研究样本主要由40至69岁的英国白人组成。尽管我们调整了潜在的混杂因素，可能还有其他未测量的和残留的混杂因素可能影响我们报告的关联.
结论：研究结果表明，与弓形虫P22相关的焦虑和癫痫的潜在证据的风险增加。然而,我们的分析并没有揭示其他几种神经精神疾病的风险增加，包括阿尔茨海默病，痴呆症,药物滥用障碍，抑郁症,和神经退行性疾病，与P22抗体血清阳性相关。
