Abstract：
OBJECTIVE: This study investigated dimension changes of various nasopharyngeal airways, including a novel self-supporting device, after saline submersion at body temperature to simulate in-vivo use. Dimension changes over time may reduce efficacy during long-term use and require sizing adjustments or limits on duration of use.
METHODS: Cuffless Covidien endotracheal tubes, pediatric Rusch fixed flange polyvinyl chloride nasal airway tubes, pediatric Rusch Robertazzi style Mediprene nasal airway tubes, and novel silicone elastomer self-supporting nasopharyngeal airways were fully submerged in 0.9 % normal saline solution incubated at 37 degrees Celsius for 15 days. All devices had tube length and wall thickness measured after 0, 1, 2, 3, 4, 5, 10, and 15 days. The 95 % confidence intervals of tube dimensions at each date were compared with the 95 % confidence intervals at day 0.
RESULTS: The Covidien ET tube, Rusch PVC NPA, and ssNPA tube lengths and wall thicknesses did not change significantly over 15 days. The Rusch Mediprene NPAs had a statistically significant increase in length starting at day 1 and wall thickness at day 2.
CONCLUSIONS: The novel ssNPA did not expand in the in-vitro environment, supporting its safety for extended use. The PVC NPA and ET tube dimensions also remained stable. However, the Rusch Mediprene NPAs had significant length expansion after 1 day of submersion, indicating a considerable risk of expansion during extended use with potential implications for patient care. Silicone and PVC NPA dimensions remained stable when saturated, indicating these materials may be more appropriate for extended use.
METHODS: Cuffless Covidien endotracheal tubes, pediatric Rusch fixed flange polyvinyl chloride nasal airway tubes, pediatric Rusch Robertazzi style Mediprene nasal airway tubes, and novel silicone elastomer self-supporting nasopharyngeal airways were fully submerged in 0.9 % normal saline solution incubated at 37 degrees Celsius for 15 days. All devices had tube length and wall thickness measured after 0, 1, 2, 3, 4, 5, 10, and 15 days. The 95 % confidence intervals of tube dimensions at each date were compared with the 95 % confidence intervals at day 0.
RESULTS: The Covidien ET tube, Rusch PVC NPA, and ssNPA tube lengths and wall thicknesses did not change significantly over 15 days. The Rusch Mediprene NPAs had a statistically significant increase in length starting at day 1 and wall thickness at day 2.
CONCLUSIONS: The novel ssNPA did not expand in the in-vitro environment, supporting its safety for extended use. The PVC NPA and ET tube dimensions also remained stable. However, the Rusch Mediprene NPAs had significant length expansion after 1 day of submersion, indicating a considerable risk of expansion during extended use with potential implications for patient care. Silicone and PVC NPA dimensions remained stable when saturated, indicating these materials may be more appropriate for extended use.
摘要：
目的：本研究调查了各种鼻咽气道的尺寸变化，包括一个新颖的自支撑装置，盐水浸没在体温下模拟体内使用。尺寸随时间的变化可能会降低长期使用期间的功效,并且需要调整尺寸或限制使用持续时间。
方法：无袖带Covidien气管导管，儿科Rusch固定法兰聚氯乙烯鼻气道管，儿科RuschRobertazzi风格的Mediprene鼻气道管，和新型有机硅弹性体自支撑鼻咽气道完全浸没在37摄氏度下孵育的0.9%生理盐水溶液中15天.所有装置具有在0、1、2、3、4、5、10和15天后测量的管长度和壁厚。将每个日期的管尺寸的95%置信区间与第0天的95%置信区间进行比较。
结果：CovidienET管，RuschPVCNPA,ssNPA管的长度和壁厚在15天内没有明显变化。从第1天开始，RuschMedipreneNPA的长度和第2天的壁厚在统计学上显着增加。
结论：新型ssNPA在体外环境中没有扩增，支持其延长使用的安全性。PVCNPA和ET管尺寸也保持稳定。然而,RuschMedipreneNPA在浸没1天后有显著的长度扩张，表明在延长使用期间存在相当大的扩张风险，对患者护理有潜在影响。有机硅和PVCNPA尺寸在饱和时保持稳定，表明这些材料可能更适合长期使用。
方法：无袖带Covidien气管导管，儿科Rusch固定法兰聚氯乙烯鼻气道管，儿科RuschRobertazzi风格的Mediprene鼻气道管，和新型有机硅弹性体自支撑鼻咽气道完全浸没在37摄氏度下孵育的0.9%生理盐水溶液中15天.所有装置具有在0、1、2、3、4、5、10和15天后测量的管长度和壁厚。将每个日期的管尺寸的95%置信区间与第0天的95%置信区间进行比较。
结果：CovidienET管，RuschPVCNPA,ssNPA管的长度和壁厚在15天内没有明显变化。从第1天开始，RuschMedipreneNPA的长度和第2天的壁厚在统计学上显着增加。
结论：新型ssNPA在体外环境中没有扩增，支持其延长使用的安全性。PVCNPA和ET管尺寸也保持稳定。然而,RuschMedipreneNPA在浸没1天后有显著的长度扩张，表明在延长使用期间存在相当大的扩张风险，对患者护理有潜在影响。有机硅和PVCNPA尺寸在饱和时保持稳定，表明这些材料可能更适合长期使用。
