Abstract：
BACKGROUND: Streptococcus suis (S. suis) disease is a zoonotic infection caused by invasive S. suis and can lead to meningitis, septic shock, arthritis, and endocarditis. Early treatment is the key to reducing mortality. However, clinical manifestations of most cases are atypical, severely limiting rapid diagnosis and treatment.
METHODS: Here, we report a 74-year-old female patient diagnosed with S. suis infection. The main symptoms were hearing loss, lumbago, and scattered ecchymosis of the lower extremities and trunk. Blood non-specific infection indexes were significantly increased and platelets were significantly decreased; however, no pathogens were obtained from routine blood culture. Finally, the S. suis infection was confirmed by metagenomic next-generation sequencing (mNGS) of blood and cerebrospinal fluid. After antibiotic treatment, the limb and trunk scattered ecchymosis and lumbago symptoms were significantly relieved, but the hearing did not recover.
CONCLUSIONS: Human infection with S. suis is rare in central cities, and it is easy to misdiagnose, especially in cases with atypical early symptoms. mNGS technology, combined with clinical observation, is helpful to clarify the direction of diagnosis and treatment, which is conducive to patient recovery.
METHODS: Here, we report a 74-year-old female patient diagnosed with S. suis infection. The main symptoms were hearing loss, lumbago, and scattered ecchymosis of the lower extremities and trunk. Blood non-specific infection indexes were significantly increased and platelets were significantly decreased; however, no pathogens were obtained from routine blood culture. Finally, the S. suis infection was confirmed by metagenomic next-generation sequencing (mNGS) of blood and cerebrospinal fluid. After antibiotic treatment, the limb and trunk scattered ecchymosis and lumbago symptoms were significantly relieved, but the hearing did not recover.
CONCLUSIONS: Human infection with S. suis is rare in central cities, and it is easy to misdiagnose, especially in cases with atypical early symptoms. mNGS technology, combined with clinical observation, is helpful to clarify the direction of diagnosis and treatment, which is conducive to patient recovery.
摘要：
背景：猪链球菌（S.suis）疾病是由侵袭性猪链球菌引起的人畜共患感染，可导致脑膜炎，感染性休克,关节炎,和心内膜炎.早期治疗是降低死亡率的关键。然而,大多数病例的临床表现不典型，严重限制了快速诊断和治疗。
方法：这里，我们报告1例74岁女性患者,诊断为猪链球菌感染.主要症状是听力损失,腰痛,下肢和躯干散见性瘀斑。血液非特异性感染指标显著升高,血小板显著降低;从常规血培养中未获得病原体。最后,猪链球菌感染通过血液和脑脊液的宏基因组下一代测序(mNGS)得到证实.抗生素治疗后，肢体和躯干散见性瘀斑和腰痛症状明显缓解，但是听证会没有恢复。
结论：中心城市很少有人感染猪链球菌，很容易误诊,尤其是早期症状不典型的病例。MNGS技术，结合临床观察,有助于明确诊断和治疗的方向，有利于患者康复。
方法：这里，我们报告1例74岁女性患者,诊断为猪链球菌感染.主要症状是听力损失,腰痛,下肢和躯干散见性瘀斑。血液非特异性感染指标显著升高,血小板显著降低;从常规血培养中未获得病原体。最后,猪链球菌感染通过血液和脑脊液的宏基因组下一代测序(mNGS)得到证实.抗生素治疗后，肢体和躯干散见性瘀斑和腰痛症状明显缓解，但是听证会没有恢复。
结论：中心城市很少有人感染猪链球菌，很容易误诊,尤其是早期症状不典型的病例。MNGS技术，结合临床观察,有助于明确诊断和治疗的方向，有利于患者康复。
