PDF(Pubmed)
Abstract：
Platelets are increasingly recognized for their multifaceted roles in inflammation beyond their traditional involvement in haemostasis. This review consolidates knowledge on platelets as critical players in inflammatory responses. This study did an extensive search of electronic databases and identified studies on platelets in inflammation, focusing on molecular mechanisms, cell interactions, and clinical implications, emphasizing recent publications. Platelets contribute to inflammation via surface receptors, release of mediators, and participation in neutrophil extracellular trap formation. They are implicated in diseases like atherosclerosis, rheumatoid arthritis, and sepsis, highlighting their interaction with immune cells as pivotal in the onset and resolution of inflammation. Platelets are central to regulating inflammation, offering new therapeutic targets for inflammatory diseases. Future research should explore specific molecular pathways of platelets in inflammation for therapeutic intervention.
摘要：
血小板因其在炎症中的多方面作用而被越来越多地认识到，而不仅仅是其在止血中的传统参与。这篇综述巩固了关于血小板作为炎症反应中关键参与者的知识。这项研究对电子数据库进行了广泛的搜索，并确定了炎症中血小板的研究，专注于分子机制，细胞相互作用，和临床意义，强调最近的出版物。血小板通过表面受体促进炎症，释放调解员,并参与中性粒细胞胞外诱捕网的形成。它们与动脉粥样硬化等疾病有关，类风湿性关节炎,和败血症,强调它们与免疫细胞的相互作用是炎症发作和消退的关键。血小板是调节炎症的核心,为炎症性疾病提供新的治疗靶点。未来的研究应探索炎症中血小板的特定分子途径以进行治疗干预。
