关键词: Down syndrome transient abnormal myelopoiesis tumor lysis syndrome

Mesh : Humans Infant, Newborn Down Syndrome Heart Failure / etiology Heart Septal Defects, Atrial / complications diagnosis Leukemoid Reaction / diagnosis Tumor Lysis Syndrome / etiology diagnosis

来  源:   DOI:10.3233/NPM-230146

Abstract:
UNASSIGNED: Tumor lysis syndrome (TLS) is an oncological emergency associated with hematological malignancies or highly proliferative solid tumors, commonly after chemotherapy. It is rarely associated with transient abnormal myelopoiesis.
UNASSIGNED: We report a rare case of a neonate with transient abnormal myelopoiesis and tumor lysis syndrome, complicated with concomitant heart failure due to an underlying atrioventricular septal defect. Hyperhydration was contraindicated due to heart failure. The patient was managed conservatively with full recovery.
UNASSIGNED: Tumor lysis syndrome should be suspected in neonates with transient abnormal myelopoiesis with electrolyte abnormalities. Treatment options should be considered carefully for their risks and benefits.
摘要:
肿瘤溶解综合征(TLS)是一种与血液恶性肿瘤或高增殖性实体瘤相关的肿瘤急症,通常在化疗后。它很少与短暂的异常骨髓生成有关。
我们报告了一例罕见的新生儿出现短暂性骨髓生成异常和肿瘤溶解综合征,并发并发因潜在的房室间隔缺损引起的心力衰竭。由于心力衰竭,水合过多是禁忌的。患者经过保守治疗,完全康复。
有电解质异常的新生儿应怀疑肿瘤溶解综合征。应仔细考虑治疗方案的风险和益处。
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