Abstract：
UNASSIGNED: Bone defects arising from diverse causes, such as traffic accidents, contemporary weapon usage, and bone-related disorders, present significant challenges in clinical treatment. Prolonged treatment cycles for bone defects can result in complications, impacting patients\' overall quality of life. Efficient and timely repair of bone defects is thus a critical concern in clinical practice.
UNASSIGNED: This study aims to assess the scientific progress and achievements of magnesium phosphate bone cement (MPC) as an artificial bone substitute material. Additionally, the research seeks to explore the future development path and clinical potential of MPC bone cement in addressing challenges associated with bone defects.
UNASSIGNED: The study comprehensively reviews MPC\'s performance, encompassing e.g. mechanical properties, biocompatibility, porosity, adhesion and injectability. Various modifiers are also considered to broaden MPC\'s applications in bone tissue engineering, emphasizing drug-loading performance and antibacterial capabilities, which meet clinical diversification requirements.
UNASSIGNED: In comparison to alternatives such as autogenous bone transplantation, allograft, polymethyl methacrylate (PMMA), and calcium phosphate cement (CPC), MPC emerges as a promising solution for bone defects. It addresses limitations associated with these alternatives, such as immunological rejection and long-term harm to patients. MPC can control heat release during the curing process, exhibits superior mechanical strength, and has the capacity to stimulate new bone growth.
UNASSIGNED: MPC stands out as an artificial bone substitute with appropriate mechanical strength, rapid degradation, non-toxicity, and good biocompatibility, facilitating bone repair and regeneration. Modification agents can enhance its clinical versatility. Future research should delve into its mechanical properties and formulations, expanding clinical applications to create higher-performing and more medically valuable alternatives in bone defect repair.
UNASSIGNED: This study aims to assess the scientific progress and achievements of magnesium phosphate bone cement (MPC) as an artificial bone substitute material. Additionally, the research seeks to explore the future development path and clinical potential of MPC bone cement in addressing challenges associated with bone defects.
UNASSIGNED: The study comprehensively reviews MPC\'s performance, encompassing e.g. mechanical properties, biocompatibility, porosity, adhesion and injectability. Various modifiers are also considered to broaden MPC\'s applications in bone tissue engineering, emphasizing drug-loading performance and antibacterial capabilities, which meet clinical diversification requirements.
UNASSIGNED: In comparison to alternatives such as autogenous bone transplantation, allograft, polymethyl methacrylate (PMMA), and calcium phosphate cement (CPC), MPC emerges as a promising solution for bone defects. It addresses limitations associated with these alternatives, such as immunological rejection and long-term harm to patients. MPC can control heat release during the curing process, exhibits superior mechanical strength, and has the capacity to stimulate new bone growth.
UNASSIGNED: MPC stands out as an artificial bone substitute with appropriate mechanical strength, rapid degradation, non-toxicity, and good biocompatibility, facilitating bone repair and regeneration. Modification agents can enhance its clinical versatility. Future research should delve into its mechanical properties and formulations, expanding clinical applications to create higher-performing and more medically valuable alternatives in bone defect repair.
摘要：
■各种原因引起的骨缺损，比如交通事故,当代武器的使用，和骨骼相关的疾病，对临床治疗提出了重大挑战。延长骨缺损的治疗周期会导致并发症，影响患者的整体生活质量。因此,有效和及时地修复骨缺损是临床实践中的关键问题。
■本研究旨在评估磷酸镁骨水泥（MPC）作为人造骨替代材料的科学进展和成就。此外,该研究旨在探索MPC骨水泥在解决与骨缺损相关的挑战方面的未来发展路径和临床潜力。
■该研究全面回顾了MPC的表现，包括例如机械性能，生物相容性，孔隙度,附着力和可注射性。各种改性剂也被认为可以拓宽MPC在骨组织工程中的应用，强调药物负载性能和抗菌能力，符合临床多样化要求。
■与自体骨移植等替代方法相比，同种异体移植,聚甲基丙烯酸甲酯(PMMA),和磷酸钙水泥(CPC)，MPC成为一种有希望的骨缺损解决方案。它解决了与这些替代方案相关的限制，如免疫排斥反应和对患者的长期伤害。MPC可以控制固化过程中的热量释放，表现出卓越的机械强度，并有能力刺激新骨生长。
■MPC是一种具有适当机械强度的人造骨替代品，快速降解，无毒性，良好的生物相容性,促进骨修复和再生。修饰剂可以增强其临床通用性。未来的研究应该深入研究其机械性能和配方，扩大临床应用，在骨缺损修复中创造更高性能和更有医学价值的替代方案。
■本研究旨在评估磷酸镁骨水泥（MPC）作为人造骨替代材料的科学进展和成就。此外,该研究旨在探索MPC骨水泥在解决与骨缺损相关的挑战方面的未来发展路径和临床潜力。
■该研究全面回顾了MPC的表现，包括例如机械性能，生物相容性，孔隙度,附着力和可注射性。各种改性剂也被认为可以拓宽MPC在骨组织工程中的应用，强调药物负载性能和抗菌能力，符合临床多样化要求。
■与自体骨移植等替代方法相比，同种异体移植,聚甲基丙烯酸甲酯(PMMA),和磷酸钙水泥(CPC)，MPC成为一种有希望的骨缺损解决方案。它解决了与这些替代方案相关的限制，如免疫排斥反应和对患者的长期伤害。MPC可以控制固化过程中的热量释放，表现出卓越的机械强度，并有能力刺激新骨生长。
■MPC是一种具有适当机械强度的人造骨替代品，快速降解，无毒性，良好的生物相容性,促进骨修复和再生。修饰剂可以增强其临床通用性。未来的研究应该深入研究其机械性能和配方，扩大临床应用，在骨缺损修复中创造更高性能和更有医学价值的替代方案。
