关键词: Blood pressure Child Hypertension PRES Pediatric

Mesh : Humans Posterior Leukoencephalopathy Syndrome / physiopathology Child Adolescent Hypertension / physiopathology Prognosis Magnetic Resonance Imaging

来  源:   DOI:10.1007/s11906-024-01303-6

Abstract:
OBJECTIVE: Posterior reversible encephalopathy syndrome, or PRES, is a constellation of severe, acute hypertension and specific brain imaging findings. This may be caused by failure of the cerebral autoregulatory system to manage acute or severe changes in blood pressure. The incidence in children is unknown but estimated to be more common in children with predisposing factors including renal disease, autoimmune disease, malignancy, solid organ transplantation, stem cell transplantation, hypertension, sepsis, and exposure to certain medications.
RESULTS: Management of PRES includes addressing hypertension, removing offending agents when possible, and anti-epileptic medications. Most children with PRES recover completely, but recurrence is possible. Lack of resolution of imaging findings likely portends a worse prognosis.
摘要:
目的:可逆性后部脑病综合征,或PRES,是一个严重的星座,急性高血压和特定的脑影像学表现。这可能是由于大脑自动调节系统无法控制血压的急性或严重变化所致。儿童的发病率未知,但估计在有肾脏疾病等诱发因素的儿童中更常见。自身免疫性疾病,恶性肿瘤,实体器官移植,干细胞移植,高血压,脓毒症,和接触某些药物。
结果:PRES的管理包括解决高血压,在可能的情况下移除违规代理人,和抗癫痫药物。大多数PRES儿童完全恢复,但复发是可能的。影像学检查结果缺乏分辨率可能预示预后较差。
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