PDF(Pubmed)
Abstract：
OBJECTIVE: Recent evidence suggested a link between periodontitis (PD) and dental caries, but the trends and nature of this association remained unclear. The overall aim of this study was to critically assess the correlation of two disorders.
METHODS: A comprehensive search was conducted within the PUBMED and EMBASE databases including grey literatures up to July 5th, 2023. The Newcastle-Ottawa scale was used to qualitatively evaluate the risk of bias.
RESULTS: Overall, 18 studies were included. In terms of caries risk in PD patients, the prevalence of caries was increased by PD (OR = 1.57, 95%CI:1.20-2.07), both in crown (OR = 1.03, 95%CI:1.01-1.05) and root caries (OR = 2.10, 95%CI:1.03-4.29). Odds of caries were also raised by PD severity (OR moderate = 1.38, 95%CI:1.15-1.66; OR severe = 2.14, 95%CI:1.74-2.64). Besides, patients with PD exhibited a higher mean number of decayed, missing and filled teeth (DMFT) and decayed and filled root teeth (DFR) [weighted mean difference (WMD)DMFT = 0.87, 95%CI: -0.03-1.76; WMDDFR = 1.13, 95%CI: 0.48-1.78]. Likewise, patients with caries had an elevated risk of PD (OR = 1.79, 95%CI:1.36-2.35). However, Streptococcus mutans, one of the main pathogens of caries, was negatively correlated with several main pathogens of periodontitis.
CONCLUSIONS: This study indicated a positive correlation between dental caries and periodontitis clinically, while the two disease-associated pathogens were antagonistic.
CONCLUSIONS: Further research, including clinical cohort studies and mechanisms of pathogens interaction is needed on this link for better prevention and treatment of PD and caries. In addition, innovative prevention strategies need to be developed and incorporated in dental practices to prevent these two highly prevalent oral diseases.
METHODS: A comprehensive search was conducted within the PUBMED and EMBASE databases including grey literatures up to July 5th, 2023. The Newcastle-Ottawa scale was used to qualitatively evaluate the risk of bias.
RESULTS: Overall, 18 studies were included. In terms of caries risk in PD patients, the prevalence of caries was increased by PD (OR = 1.57, 95%CI:1.20-2.07), both in crown (OR = 1.03, 95%CI:1.01-1.05) and root caries (OR = 2.10, 95%CI:1.03-4.29). Odds of caries were also raised by PD severity (OR moderate = 1.38, 95%CI:1.15-1.66; OR severe = 2.14, 95%CI:1.74-2.64). Besides, patients with PD exhibited a higher mean number of decayed, missing and filled teeth (DMFT) and decayed and filled root teeth (DFR) [weighted mean difference (WMD)DMFT = 0.87, 95%CI: -0.03-1.76; WMDDFR = 1.13, 95%CI: 0.48-1.78]. Likewise, patients with caries had an elevated risk of PD (OR = 1.79, 95%CI:1.36-2.35). However, Streptococcus mutans, one of the main pathogens of caries, was negatively correlated with several main pathogens of periodontitis.
CONCLUSIONS: This study indicated a positive correlation between dental caries and periodontitis clinically, while the two disease-associated pathogens were antagonistic.
CONCLUSIONS: Further research, including clinical cohort studies and mechanisms of pathogens interaction is needed on this link for better prevention and treatment of PD and caries. In addition, innovative prevention strategies need to be developed and incorporated in dental practices to prevent these two highly prevalent oral diseases.
摘要：
目的：最近的证据表明牙周炎（PD）与龋齿之间存在联系，但这种关联的趋势和性质尚不清楚.这项研究的总体目标是严格评估两种疾病的相关性。
方法：在PUBMED和EMBASE数据库中进行了全面搜索，包括截至7月5日的灰色文献，2023年。纽卡斯尔-渥太华量表用于定性评估偏倚风险。
结果：总体而言，共纳入18项研究。就PD患者的龋齿风险而言，龋齿患病率增加PD（OR=1.57，95CI：1.20-2.07），牙冠(OR=1.03,95CI:1.01-1.05)和牙根龋(OR=2.10,95CI:1.03-4.29)。PD严重程度也增加了龋齿的几率（OR中度=1.38，95CI：1.15-1.66；OR重度=2.14，95CI：1.74-2.64）。此外,PD患者表现出更高的平均衰变数，缺失和填充牙(DMFT)和腐烂和填充根牙(DFR)[加权平均差(WMD)DMFT=0.87,95CI:-0.03-1.76;WMDDFR=1.13,95CI:0.48-1.78]。同样，龋齿患者的PD风险升高(OR=1.79,95CI:1.36~2.35).然而,变形链球菌,龋齿的主要病原体之一，与牙周炎的几种主要病原菌呈负相关。
结论：这项研究表明，临床上龋齿与牙周炎呈正相关，而两种疾病相关病原体是拮抗的。
结论：进一步的研究，包括临床队列研究和病原体相互作用的机制需要在这一环节，以更好地预防和治疗PD和龋齿。此外,需要制定创新的预防策略，并将其纳入牙科实践，以预防这两种高度流行的口腔疾病。
方法：在PUBMED和EMBASE数据库中进行了全面搜索，包括截至7月5日的灰色文献，2023年。纽卡斯尔-渥太华量表用于定性评估偏倚风险。
结果：总体而言，共纳入18项研究。就PD患者的龋齿风险而言，龋齿患病率增加PD（OR=1.57，95CI：1.20-2.07），牙冠(OR=1.03,95CI:1.01-1.05)和牙根龋(OR=2.10,95CI:1.03-4.29)。PD严重程度也增加了龋齿的几率（OR中度=1.38，95CI：1.15-1.66；OR重度=2.14，95CI：1.74-2.64）。此外,PD患者表现出更高的平均衰变数，缺失和填充牙(DMFT)和腐烂和填充根牙(DFR)[加权平均差(WMD)DMFT=0.87,95CI:-0.03-1.76;WMDDFR=1.13,95CI:0.48-1.78]。同样，龋齿患者的PD风险升高(OR=1.79,95CI:1.36~2.35).然而,变形链球菌,龋齿的主要病原体之一，与牙周炎的几种主要病原菌呈负相关。
结论：这项研究表明，临床上龋齿与牙周炎呈正相关，而两种疾病相关病原体是拮抗的。
结论：进一步的研究，包括临床队列研究和病原体相互作用的机制需要在这一环节，以更好地预防和治疗PD和龋齿。此外,需要制定创新的预防策略，并将其纳入牙科实践，以预防这两种高度流行的口腔疾病。
