Abstract:
Acacia nilotica L., also known as babul, belonging to the Fabaceae family and the Acacia genus, is typically used for ornamental purposes and also as a medicinal plant found in tropical and subtropical areas. This plant is a rich source of bioactive compounds. The current study aimed to elucidate the hypoglycemic, anti-inflammatory, and neuroprotective potential of A. nilotica\'s crude methanolic extract. The results of the in vitro antidiabetic assay revealed that methanolic extract of A. nilotica inhibited the enzyme α-glucosidase (IC50: 33 μg mL-1) and α-amylase (IC50: 17 μg mL-1) in a dose-dependent manner. While in the anticholinesterase enzyme inhibitory assay, maximum inhibition was shown by the extract against acetylcholinesterase (AChE) (637.01 μg mL-1) and butyrylcholinesterase (BChE) (491.98 μg mL-1), with the highest percent inhibition of 67.54% and 71.50% at 1000 μg mL-1, respectively. This inhibitory potential was lower as compared to the standard drug Galantamine that exhibited 82.43 and 89.50% inhibition at the same concentration, respectively. Moreover, the methanolic extract of A. nilotica also significantly inhibited the activities of cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) in a concentration-dependent manner. The percent inhibitory activity of 5-LOX and COX-2 ranged from 42.47% to 71.53% and 43.48% to 75.22%, respectively. Furthermore, in silico, in vivo, and clinical investigations must be planned to validate the above-stated bioactivities of A. nilotica.
摘要:
金合欢,也被称为Babul,属于豆科和相思属,通常用于观赏目的,也可用作热带和亚热带地区的药用植物。这种植物是生物活性化合物的丰富来源。目前的研究旨在阐明低血糖,抗炎,和神经保护潜力。体外抗糖尿病测定的结果表明,尼罗狄卡的甲醇提取物以剂量依赖性方式抑制酶α-葡萄糖苷酶(IC50:33μgmL-1)和α-淀粉酶(IC50:17μgmL-1)。而在抗胆碱酯酶酶抑制试验中,提取物对乙酰胆碱酯酶(AChE)(637.01μgmL-1)和丁酰胆碱酯酶(BChE)(491.98μgmL-1)的最大抑制作用,在1000μgmL-1时,最高的抑制百分比分别为67.54%和71.50%。与在相同浓度下表现出82.43和89.50%抑制作用的标准药物加兰他敏相比,这种抑制潜力较低,分别。此外,尼罗天麻的甲醇提取物还以浓度依赖性方式显着抑制环氧合酶2(COX-2)和5-脂氧合酶(5-LOX)的活性。5-LOX和COX-2的抑制活性百分比范围为42.47%至71.53%和43.48%至75.22%,分别。此外,在硅,在体内,并且必须计划进行临床研究,以验证尼罗替卡的上述生物活性。