PDF(Pubmed)
Abstract：
Acacia nilotica L., also known as babul, belonging to the Fabaceae family and the Acacia genus, is typically used for ornamental purposes and also as a medicinal plant found in tropical and subtropical areas. This plant is a rich source of bioactive compounds. The current study aimed to elucidate the hypoglycemic, anti-inflammatory, and neuroprotective potential of A. nilotica\'s crude methanolic extract. The results of the in vitro antidiabetic assay revealed that methanolic extract of A. nilotica inhibited the enzyme α-glucosidase (IC50: 33 μg mL-1) and α-amylase (IC50: 17 μg mL-1) in a dose-dependent manner. While in the anticholinesterase enzyme inhibitory assay, maximum inhibition was shown by the extract against acetylcholinesterase (AChE) (637.01 μg mL-1) and butyrylcholinesterase (BChE) (491.98 μg mL-1), with the highest percent inhibition of 67.54% and 71.50% at 1000 μg mL-1, respectively. This inhibitory potential was lower as compared to the standard drug Galantamine that exhibited 82.43 and 89.50% inhibition at the same concentration, respectively. Moreover, the methanolic extract of A. nilotica also significantly inhibited the activities of cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) in a concentration-dependent manner. The percent inhibitory activity of 5-LOX and COX-2 ranged from 42.47% to 71.53% and 43.48% to 75.22%, respectively. Furthermore, in silico, in vivo, and clinical investigations must be planned to validate the above-stated bioactivities of A. nilotica.
摘要：
金合欢，也被称为Babul，属于豆科和相思属，通常用于观赏目的，也可用作热带和亚热带地区的药用植物。这种植物是生物活性化合物的丰富来源。目前的研究旨在阐明低血糖，抗炎,和神经保护潜力。体外抗糖尿病测定的结果表明，尼罗狄卡的甲醇提取物以剂量依赖性方式抑制酶α-葡萄糖苷酶（IC50：33μgmL-1）和α-淀粉酶（IC50：17μgmL-1）。而在抗胆碱酯酶酶抑制试验中，提取物对乙酰胆碱酯酶（AChE）（637.01μgmL-1）和丁酰胆碱酯酶（BChE）（491.98μgmL-1）的最大抑制作用，在1000μgmL-1时，最高的抑制百分比分别为67.54％和71.50％。与在相同浓度下表现出82.43和89.50%抑制作用的标准药物加兰他敏相比，这种抑制潜力较低，分别。此外，尼罗天麻的甲醇提取物还以浓度依赖性方式显着抑制环氧合酶2（COX-2）和5-脂氧合酶（5-LOX）的活性。5-LOX和COX-2的抑制活性百分比范围为42.47％至71.53％和43.48％至75.22％，分别。此外，在硅，在体内，并且必须计划进行临床研究，以验证尼罗替卡的上述生物活性。
