PDF(Pubmed)
Abstract：
Objectives: We aimed to evaluate changes to measles-containing vaccine (MCV) provision and subsequent measles disease cases in low- and lower-middle income countries (LICs, LMICs) in relation to the COVID-19 pandemic. Methods: A systematic search was conducted of MEDLINE, OVID EMBASE and PubMed records. Primary quantitative and qualitative research studies published from January 2020 were included if they reported on COVID-19 impact on MCV provision and/or measles outbreak rates within LICs and LMICs. Results: 45 studies were included. The change in MCV1 vaccination coverage in national and international regions ranged -13% to +44.4% from pre-COVID time periods. In local regions, the median MCV1 and overall EPI rate changed by -23.3% and -28.5% respectively. Median MCV2 rate was disproportionally impacted in local areas during COVID-interruption time-periods (-48.2%) with ongoing disruption in early-recovery time-periods (-17.7%). 8.9% of studies reported on vaccination status of confirmed measles cases; from these, 71%-91% had received no MCV dose. Conclusion: MCV vaccination coverage experienced ongoing disruption during the recovery periods after initial COVID-19 disruption. Vaccination in local area datasets notably experienced longer-term disruption compared to nationally reported figures.
摘要：
目标：我们旨在评估低收入和中低收入国家（LICs，LMIC）与COVID-19大流行有关。方法:系统检索MEDLINE,OVIDEMBASE和PubMed记录。包括2020年1月发表的主要定量和定性研究研究，如果它们报告了COVID-19对低收入国家和低收入国家内MCV供应和/或麻疹暴发率的影响。结果：共纳入45项研究。与COVID前时间段相比，国家和国际地区的MCV1疫苗接种覆盖率变化范围为-13%至+44.4%。在当地,MCV1中位数和总EPI率分别变化-23.3%和-28.5%.在COVID中断时间段内，局部地区的MCV2中位数受到不成比例的影响（-48.2％），在早期恢复时间段内持续中断（-17.7％）。8.9%的研究报告了确诊麻疹病例的疫苗接种状况；71%-91%未接受MCV剂量。结论：在初次COVID-19中断后的恢复期，MCV疫苗接种覆盖率经历了持续的中断。与国家报告的数字相比，当地数据集中的疫苗接种尤其经历了长期的中断。
