PDF(Pubmed)
Abstract：
UNASSIGNED: Mechanical stress and strain conditions play an important role in atherosclerosis plaque progression, remodeling and potential rupture and may be used in plaque vulnerability assessment for better clinical diagnosis and treatment decisions. Single layer plaque models without residual stress have been widely used due to unavailability of multi-layer image segmentation method and residual stress data. However, vessel layered structure and residual stress have large impact on stress/strain calculations and should be included in the models.
UNASSIGNED: In this study, intravascular optical coherence tomography (OCT) data of coronary plaques from 10 patients were acquired and segmented to obtain the three-layer vessel structure using an in-house automatic segmentation algorithm. Multi- and single-layer 3D thin-slice biomechanical plaque models with and without residual stress were constructed to assess the impact of residual stress on stress/strain calculations.
UNASSIGNED: Our results showed that residual stress led to a more uniform stress distribution across the vessel wall, with considerable plaque stress/strain decrease on inner wall and increase on vessel out-wall. Multi-layer model with residual stress inclusion reduced inner wall maximum and mean plaque stresses by 38.57% and 59.70%, and increased out-wall maximum and mean plaque stresses by 572.84% and 432.03%.
UNASSIGNED: These findings demonstrated the importance of multi-layer modeling with residual stress for more accurate plaque stress/strain calculations, which will have great impact in plaque cap stress calculation and plaque rupture risk assessment. Further large-scale studies are needed to validate our findings.
UNASSIGNED: In this study, intravascular optical coherence tomography (OCT) data of coronary plaques from 10 patients were acquired and segmented to obtain the three-layer vessel structure using an in-house automatic segmentation algorithm. Multi- and single-layer 3D thin-slice biomechanical plaque models with and without residual stress were constructed to assess the impact of residual stress on stress/strain calculations.
UNASSIGNED: Our results showed that residual stress led to a more uniform stress distribution across the vessel wall, with considerable plaque stress/strain decrease on inner wall and increase on vessel out-wall. Multi-layer model with residual stress inclusion reduced inner wall maximum and mean plaque stresses by 38.57% and 59.70%, and increased out-wall maximum and mean plaque stresses by 572.84% and 432.03%.
UNASSIGNED: These findings demonstrated the importance of multi-layer modeling with residual stress for more accurate plaque stress/strain calculations, which will have great impact in plaque cap stress calculation and plaque rupture risk assessment. Further large-scale studies are needed to validate our findings.
摘要：
■机械应力和应变条件在动脉粥样硬化斑块进展中起重要作用，重塑和潜在的破裂，可用于斑块易损性评估，以获得更好的临床诊断和治疗决策。由于多层图像分割方法和残余应力数据的不可用性，无残余应力的单层斑块模型得到了广泛的应用。然而,容器分层结构和残余应力对应力/应变计算有很大影响，应包括在模型中。
■在这项研究中，我们采集了10例患者的冠状动脉斑块的血管内光学相干断层扫描(OCT)数据,并使用内部自动分割算法对其进行分割以获得三层血管结构.构建了具有和不具有残余应力的多层和单层3D薄层生物力学斑块模型，以评估残余应力对应力/应变计算的影响。
■我们的结果表明，残余应力导致整个血管壁的应力分布更均匀，随着相当大的斑块应力/应变在内壁减少，在血管外增加。包含残余应力的多层模型使内壁最大和平均斑块应力降低了38.57％和59.70％，壁外最大和平均斑块应力分别增加了572.84％和432.03％。
■这些发现证明了具有残余应力的多层建模对于更精确的斑块应力/应变计算的重要性，这将对斑块盖应力计算和斑块破裂风险评估产生很大影响。需要进一步的大规模研究来验证我们的发现。
■在这项研究中，我们采集了10例患者的冠状动脉斑块的血管内光学相干断层扫描(OCT)数据,并使用内部自动分割算法对其进行分割以获得三层血管结构.构建了具有和不具有残余应力的多层和单层3D薄层生物力学斑块模型，以评估残余应力对应力/应变计算的影响。
■我们的结果表明，残余应力导致整个血管壁的应力分布更均匀，随着相当大的斑块应力/应变在内壁减少，在血管外增加。包含残余应力的多层模型使内壁最大和平均斑块应力降低了38.57％和59.70％，壁外最大和平均斑块应力分别增加了572.84％和432.03％。
■这些发现证明了具有残余应力的多层建模对于更精确的斑块应力/应变计算的重要性，这将对斑块盖应力计算和斑块破裂风险评估产生很大影响。需要进一步的大规模研究来验证我们的发现。
