PDF(Pubmed)
Abstract：
Background General anaesthesia (GA) is predominantly important for conducting tracheal intubation; it should be quick and precise, having a prudent performance. It is preferable to use a neuromuscular blocking drug, which ideally should be highly potent, with a rapid onset and a short duration clinical effect in order to prevent the development of hypoxia during laryngoscopy and tracheal intubation and also avoid any changes in haemodynamics caused by the release of histamine, ganglion block, and anti-muscarinic actions. The non-depolarizing muscle relaxants rocuronium and cisatracurium don\'t have any noticeable independent side effects when used within the recommended dosage levels. Aim The aim was to compare the clinical efficacy of rocuronium bromide and cisatracurium besylate with respect to their property as muscle relaxants in producing favourable intubating conditions and to assess their haemodynamic stability. The objectives of the study were to evaluate the onset of action and any undesirable effects. Methods Between the ages of 20 to 60 years, 60 patients of either gender, divided randomly into groups of 30 each, of American Society of Anesthesiologists (ASA) physical status classification I and II, were put for elective surgical procedures to be done under general anaesthesia. Patients were given 0.6 mg kg-1 IV of rocuronium in Group R and 0.15 mg kg-1 IV of cisatracurium in Group C. After injecting the muscle relaxants, parameters were measured 60, 90, 120, 150, 180, 240, and 300 seconds later. Result Demographical variables like age, gender, and ASA physical status of the two groups were analogous. Group R had good to excellent/favourable intubating conditions by 90 seconds, and Group C by 240 seconds with comparable haemodynamic stability. The onset of action was significantly faster in Group R (92 ± 7.61 seconds) than in Group C (188 ± 40.88 seconds). Conclusion Rocuronium produced favourable intubating conditions having good haemodynamic stability and a statistically significant (p < 0.00001) faster onset of action in comparison to cisatracurium.
摘要：
背景全身麻醉（GA）对于进行气管插管至关重要；它应该快速而精确，有一个谨慎的表现。最好使用神经肌肉阻滞药物，理想情况下应该是高度有效的，具有快速起效和短期临床效果，以防止喉镜和气管插管期间缺氧的发展，并避免由组胺释放引起的血流动力学的任何变化，神经节阻滞,和抗毒蕈碱的行动。非去极化肌肉松弛剂罗库溴铵和顺式阿曲库铵在推荐剂量水平内使用时没有任何明显的独立副作用。目的比较罗库溴铵和苯磺酸顺式阿曲库铵作为肌肉松弛剂在产生有利插管条件方面的临床疗效，并评估其血液动力学稳定性。研究的目的是评估作用的开始和任何不良作用。方法年龄在20至60岁之间,60名男女患者，随机分成每组30人,美国麻醉医师协会（ASA）的身体状况分类I和II，在全身麻醉下进行选择性外科手术。在注射肌肉松弛剂后，患者在R组中给予0.6mgkg-1IV的罗库溴铵和在C组中给予0.15mgkg-1IV的顺式阿曲库铵。在60、90、120、150、180、240和300秒后测量参数。结果人口统计学变量，如年龄，性别,两组的ASA身体状况相似。到90秒时，R组的插管条件良好到良好/有利，和C组240秒，血液动力学稳定性相当。R组（92±7.61秒）的起效明显快于C组（188±40.88秒）。结论与顺式阿曲库铵相比，罗库溴铵产生了良好的插管条件，具有良好的血液动力学稳定性和统计学意义（p<0.00001）更快的起效。
