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Abstract：
Objectives To determine the prevalence of gastroesophageal reflux disease (GERD) after laparoscopic sleeve gastrectomy (LSG) and associated factors. Methods A cross-sectional study was conducted in different regions around the Kingdom of Saudi Arabia between 2022 and 2023. The questionnaire was distributed among patients who underwent LSG at different periods, ranging from six months to more than two years. The questionnaire comprised a risk factor assessment and the GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire. Results A total of 387 participants with a mean age of 35.7±10.95 were included. The study included 225 females (58.1%) and 162 males (41.9%). The mean preoperative body mass index (BMI) was 44.36±8.07 kg/m2, which decreased to 28.78±6.31 kg/m2 postoperatively. Notably, dissatisfaction with general health surged from 17 (24.6%) preoperatively to 165 (42.6%) postoperatively. Despite no significant difference in GERD-HRQL scores in the group who had preoperative symptoms, 282 (72.9%) reported experiencing heartburn, and 289 (74.7%) reported bloating postoperatively. Postoperatively, 203 (52.5%) reported improved quality of life. Moreover, changes in BMI were strongly correlated with heartburn, dysphagia, odynophagia, and bloating. The postoperative prevalence of GERD was 355 (91.7%), with 318 (82.2%) of participants reporting new-onset symptoms. Sex (P=0.013), age (P=0.024), and hypercholesterolemia (P=0.046) were significantly associated with postoperative GERD severity. Conclusions The majority of participants developed GERD symptoms following surgery, with a significant proportion reporting new-onset symptoms. Sex, age, and hypercholesterolemia have emerged as significant factors for postoperative GERD severity.
摘要：
目的探讨腹腔镜袖状胃切除术(LSG)后胃食管反流病(GERD)的发生率及相关因素。方法2022年至2023年在沙特阿拉伯王国周围不同地区进行了横断面研究。问卷分布在不同时期接受LSG的患者中，从六个月到两年不等。问卷包括危险因素评估和GERD-健康相关生活质量（GERD-HRQL）问卷。结果共纳入387名参与者，平均年龄为35.7±10.95。该研究包括225名女性（58.1％）和162名男性（41.9％）。术前平均体重指数（BMI）为44.36±8.07kg/m2，术后下降至28.78±6.31kg/m2。值得注意的是,对一般健康状况的不满从术前的17例（24.6％）激增至术后的165例（42.6％）。尽管在有术前症状的组中GERD-HRQL评分没有显着差异，282（72.9%）报告经历胃灼热，289例（74.7%）报告术后腹胀。术后,203（52.5%）报告生活质量改善。此外，BMI的变化与胃灼热密切相关，吞咽困难,吞咽困难,和腹胀。术后GERD患病率为355例(91.7%),318（82.2%）参与者报告新发症状。性别（P=0.013），年龄（P=0.024），高胆固醇血症(P=0.046)与术后GERD严重程度显著相关。结论大多数参与者在手术后出现GERD症状，报告新发症状的比例很大。性,年龄,高胆固醇血症已成为术后GERD严重程度的重要因素.
