PDF(Pubmed)
Abstract：
Cancer immunotherapy has recently emerged as a key strategy for cancer treatment. TREM2, a key target for regulating the tumor immune microenvironment, is important in cancer treatment and progression. TREM2 is an immune signaling hub that regulates multiple pathological pathways. It not only suppresses anti-tumor immune responses by inhibiting T cell-mediated immune responses, but it also influences tumorigenesis by affecting NK cell-mediated anti-tumor immunity. Noticeably, TREM2 expression levels also vary significantly among different tumor cells, and it can regulate tumor progression by modulating various signaling pathways. Above all, by summarizing the role of TREM2 in cancer immunotherapy and the mechanism by which TREM2 regulates tumor progression, this paper clarifies TREM2\'s role in both tumor progression and cancer therapy, identifying a new therapeutic target for oncology diseases.
摘要：
癌症免疫疗法最近已成为癌症治疗的关键策略。TREM2是调节肿瘤免疫微环境的关键靶点,在癌症治疗和进展中很重要。TREM2是调节多种病理途径的免疫信号中枢。它不仅通过抑制T细胞介导的免疫反应来抑制抗肿瘤免疫反应，但它也通过影响NK细胞介导的抗肿瘤免疫影响肿瘤发生。值得注意的是，TREM2表达水平在不同肿瘤细胞之间也有显著差异。它可以通过调节各种信号通路来调节肿瘤的进展。最重要的是,通过总结TREM2在癌症免疫治疗中的作用以及TREM2调节肿瘤进展的机制，本文阐明了TREM2在肿瘤进展和癌症治疗中的作用，确定肿瘤疾病的新治疗靶点。
