PDF(Pubmed)
Abstract：
UNASSIGNED: Enteral nutrition is a very important form of treatment for critically ill patients. This meta-analysis aimed to evaluate the clinical effects and safety of semi-solid feeds in tube-fed patients.
UNASSIGNED: Two researchers searched PubMed, clinical trials, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Weipu databases for randomized controlled trials (RCTs) on the clinical effects and safety of semi-solid feeds in tube-fed patients until 10 October 2023. The quality evaluation tool recommended by the Cochrane Library was used to evaluate the quality of included RCTs. RevMan 5.4 software was used for data analysis.
UNASSIGNED: A total of eight RCTs involving 823 tube-fed patients were included in this meta-analysis. A synthesized outcome indicated that semi-solid feeds reduced the incidence of diarrhea (RR = 0.32, 95%CI:0.20-0.50, P < 0.001), vomiting (RR = 0.31, 95%CI:0.15-0.64, P = 0.002), abdominal distension (RR = 0.41, 95%CI:0.22-0.76, P = 0.005), length of intensive care unit (ICU) stay (MD = -3.61, 95%CI: -6.74 to -0.48, P = 0.02), and length of hospital stay (MD = -7.14, 95%CI: -10.31 to -3.97, P < 0.01) in tube-fed patients. Enteric feeding had no effect on the 30-day mortality (RR = 0.55, 95%CI: 0.19-1.56, P = 0.26). No publication bias was detected by the Egger\'s test results (all P > 0.05).
UNASSIGNED: Semi-solid feeds are beneficial in reducing the incidence of diarrhea, abdominal distension, vomiting, and hospital stay. More high-quality studies are needed in the future to verify the effects of semi-solid feeds on mortality.
UNASSIGNED: Two researchers searched PubMed, clinical trials, Embase, Cochrane Central Register of Controlled Trials, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Weipu databases for randomized controlled trials (RCTs) on the clinical effects and safety of semi-solid feeds in tube-fed patients until 10 October 2023. The quality evaluation tool recommended by the Cochrane Library was used to evaluate the quality of included RCTs. RevMan 5.4 software was used for data analysis.
UNASSIGNED: A total of eight RCTs involving 823 tube-fed patients were included in this meta-analysis. A synthesized outcome indicated that semi-solid feeds reduced the incidence of diarrhea (RR = 0.32, 95%CI:0.20-0.50, P < 0.001), vomiting (RR = 0.31, 95%CI:0.15-0.64, P = 0.002), abdominal distension (RR = 0.41, 95%CI:0.22-0.76, P = 0.005), length of intensive care unit (ICU) stay (MD = -3.61, 95%CI: -6.74 to -0.48, P = 0.02), and length of hospital stay (MD = -7.14, 95%CI: -10.31 to -3.97, P < 0.01) in tube-fed patients. Enteric feeding had no effect on the 30-day mortality (RR = 0.55, 95%CI: 0.19-1.56, P = 0.26). No publication bias was detected by the Egger\'s test results (all P > 0.05).
UNASSIGNED: Semi-solid feeds are beneficial in reducing the incidence of diarrhea, abdominal distension, vomiting, and hospital stay. More high-quality studies are needed in the future to verify the effects of semi-solid feeds on mortality.
摘要：
■肠内营养是危重患者非常重要的治疗方式。这项荟萃分析旨在评估半固体饲料在管饲患者中的临床效果和安全性。
■两名研究人员搜索了PubMed，临床试验,Embase,Cochrane中央控制试验登记册,WebofScience,科克伦图书馆,中国国家知识基础设施(CNKI),万方数据,和Weipu数据库的随机对照试验（RCT）的临床效果和安全性的半固体饲料在管饲患者直到2023年10月10日。使用Cochrane图书馆推荐的质量评估工具来评估所包含的RCT的质量。采用RevMan5.4软件进行数据分析。
■本荟萃分析共纳入了8个RCT，涉及823名接受管饲的患者。综合结果表明，半固体饲料降低了腹泻的发生率（RR=0.32，95CI：0.20-0.50，P<0.001），呕吐（RR=0.31，95CI：0.15-0.64，P=0.002），腹胀（RR=0.41，95CI：0.22-0.76，P=0.005），重症监护病房（ICU）住院时间（MD=-3.61，95CI：-6.74至-0.48，P=0.02），管饲患者的住院时间（MD=-7.14，95CI：-10.31至-3.97，P<0.01）。肠道喂养对30天死亡率无影响(RR=0.55,95CI:0.19-1.56,P=0.26)。Egger检验结果未发现发表偏倚(P均>0.05)。
■半固体饲料有利于降低腹泻的发生率，腹胀,呕吐,住院。未来需要更多高质量的研究来验证半固体饲料对死亡率的影响。
■两名研究人员搜索了PubMed，临床试验,Embase,Cochrane中央控制试验登记册,WebofScience,科克伦图书馆,中国国家知识基础设施(CNKI),万方数据,和Weipu数据库的随机对照试验（RCT）的临床效果和安全性的半固体饲料在管饲患者直到2023年10月10日。使用Cochrane图书馆推荐的质量评估工具来评估所包含的RCT的质量。采用RevMan5.4软件进行数据分析。
■本荟萃分析共纳入了8个RCT，涉及823名接受管饲的患者。综合结果表明，半固体饲料降低了腹泻的发生率（RR=0.32，95CI：0.20-0.50，P<0.001），呕吐（RR=0.31，95CI：0.15-0.64，P=0.002），腹胀（RR=0.41，95CI：0.22-0.76，P=0.005），重症监护病房（ICU）住院时间（MD=-3.61，95CI：-6.74至-0.48，P=0.02），管饲患者的住院时间（MD=-7.14，95CI：-10.31至-3.97，P<0.01）。肠道喂养对30天死亡率无影响(RR=0.55,95CI:0.19-1.56,P=0.26)。Egger检验结果未发现发表偏倚(P均>0.05)。
■半固体饲料有利于降低腹泻的发生率，腹胀,呕吐,住院。未来需要更多高质量的研究来验证半固体饲料对死亡率的影响。
