PDF(Pubmed)
Abstract：
UNASSIGNED: Kimura disease is characterized by inflammation, with its underlying causes remaining uncertain. There is a lack of comprehensive and systematic research on the pathology of this condition in pediatric patients. Our objective is to study the clinical and pathological attributes of Kimura disease in pediatric patients and investigate the potential diagnostic significance of immunoglobulin E (IgE) in this context.
UNASSIGNED: Clinical and laboratory information, pathological characteristics, and follow-up data were correlated to examine the distinctive features. Immunohistochemistry, acid-fast staining, and molecular assay were used to identify the presence of IgE and pathogens.
UNASSIGNED: We conducted an analysis of five cases of Kimura disease in pediatric patients at our hospital. The patients\' ages ranged from 5 years and 7 months to 14 years and 2 months, with 4 (80%) being male. The most common site was the head and neck region, particularly the postauricular subcutaneous area. Eosinophilia was observed in four patients (80%), and two patients (40%) had elevated serum immunoglobulin E (IgE) levels. Histopathological changes included eosinophilic infiltrates, follicular hyperplasia, and the proliferation of postcapillary venules. Immunohistochemical results supported the reactive nature of the lymphoid process and IgE deposition in the follicle, while no specific pathogens were discovered by special staining. All patients underwent surgical excision, and none experienced recurrence in their original location.
UNASSIGNED: Children with Kimura disease show distinct eosinophilic and IgE alterations in both laboratory findings and pathological features. The application of immunohistochemical staining of IgE could serve as a promising marker for diagnosing Kimura disease.
UNASSIGNED: Clinical and laboratory information, pathological characteristics, and follow-up data were correlated to examine the distinctive features. Immunohistochemistry, acid-fast staining, and molecular assay were used to identify the presence of IgE and pathogens.
UNASSIGNED: We conducted an analysis of five cases of Kimura disease in pediatric patients at our hospital. The patients\' ages ranged from 5 years and 7 months to 14 years and 2 months, with 4 (80%) being male. The most common site was the head and neck region, particularly the postauricular subcutaneous area. Eosinophilia was observed in four patients (80%), and two patients (40%) had elevated serum immunoglobulin E (IgE) levels. Histopathological changes included eosinophilic infiltrates, follicular hyperplasia, and the proliferation of postcapillary venules. Immunohistochemical results supported the reactive nature of the lymphoid process and IgE deposition in the follicle, while no specific pathogens were discovered by special staining. All patients underwent surgical excision, and none experienced recurrence in their original location.
UNASSIGNED: Children with Kimura disease show distinct eosinophilic and IgE alterations in both laboratory findings and pathological features. The application of immunohistochemical staining of IgE could serve as a promising marker for diagnosing Kimura disease.
摘要：
■木村病以炎症为特征，其根本原因仍然不确定。缺乏对儿科患者这种情况的病理学的全面和系统的研究。我们的目的是研究小儿Kimura病的临床和病理特征，并探讨在这种情况下免疫球蛋白E（IgE）的潜在诊断意义。
■临床和实验室信息，病理特征，并对随访数据进行相关性分析,以检查其显著特征.免疫组织化学,耐酸染色,和分子检测用于鉴定IgE和病原体的存在。
■我们对我院5例儿科患者的木村病进行了分析。患者年龄5岁7个月至14岁2个月,其中4人（80%）为男性。最常见的部位是头颈部，特别是耳后皮下区域。4例患者（80%）出现嗜酸性粒细胞增多，两名患者（40％）的血清免疫球蛋白E（IgE）水平升高。组织病理学改变包括嗜酸性粒细胞浸润，卵泡增生,和毛细血管后小静脉的增殖。免疫组织化学结果支持淋巴样过程的反应性质和卵泡中的IgE沉积，而通过特殊染色没有发现特定的病原体。所有患者均接受手术切除,没有人在原来的位置复发。
木村病患儿在实验室检查结果和病理特征中均表现出明显的嗜酸性粒细胞和IgE改变。IgE的免疫组织化学染色的应用可以作为诊断木村病的有希望的标志物。
■临床和实验室信息，病理特征，并对随访数据进行相关性分析,以检查其显著特征.免疫组织化学,耐酸染色,和分子检测用于鉴定IgE和病原体的存在。
■我们对我院5例儿科患者的木村病进行了分析。患者年龄5岁7个月至14岁2个月,其中4人（80%）为男性。最常见的部位是头颈部，特别是耳后皮下区域。4例患者（80%）出现嗜酸性粒细胞增多，两名患者（40％）的血清免疫球蛋白E（IgE）水平升高。组织病理学改变包括嗜酸性粒细胞浸润，卵泡增生,和毛细血管后小静脉的增殖。免疫组织化学结果支持淋巴样过程的反应性质和卵泡中的IgE沉积，而通过特殊染色没有发现特定的病原体。所有患者均接受手术切除,没有人在原来的位置复发。
木村病患儿在实验室检查结果和病理特征中均表现出明显的嗜酸性粒细胞和IgE改变。IgE的免疫组织化学染色的应用可以作为诊断木村病的有希望的标志物。
