Abstract：
Tumor-induced osteomalacia (TIO) is a disorder in which the clinical signs and symptoms of osteomalacia and the biochemical abnormalities of hypophosphatemia, phosphaturia, and low serum levels of 1,25(OH)2 Vitamin D3 are secondary to a neoplasm. A 33-year-old woman presented with musculoskeletal pain and proximal myopathy with a duration of 2.5 years which was treated with Vitamin D supplements. On the basis of the biochemical tests and histopathology, she was reevaluated and found to have TIO secondary to a phosphaturic mesenchymal tumor. The tumor was resected (limb salvage with endoprosthesis), and she had no pain or weakness at followup. The case reminds the readers to consider the possibility of TIO when evaluating patients with isolated hypophosphatemia, which may lead to long-term disability and prolonged morbidity if untreated. Early recognition and diagnosis of TIO is crucial since resection of the tumor usually reverses its manifestations.
摘要：
肿瘤诱导的骨软化症（TIO）是一种疾病，其中骨软化症的临床体征和症状以及低磷酸盐血症的生化异常，磷尿，低血清水平的1,25(OH)2维生素D3是继发于肿瘤。一名33岁的妇女出现肌肉骨骼疼痛和近端肌病，持续时间为2.5年，接受维生素D补充剂治疗。根据生化检查和组织病理学，对她进行了重新评估,发现她的TIO继发于磷酸盐性间充质肿瘤.切除肿瘤（用内置假体进行肢体抢救），她在随访中没有疼痛或虚弱。该案例提醒读者在评估孤立性低磷酸盐血症患者时考虑TIO的可能性，如果不治疗，可能导致长期残疾和长期发病。TIO的早期识别和诊断至关重要，因为肿瘤的切除通常会逆转其表现。
