Abstract：
OBJECTIVE: In adults, diets rich in protein seem beneficial in relation to satiety, weight loss, and weight management; however, studies investigating dietary protein and weight development in children are scarce and inconsistent. This nonrandomized controlled trial aimed to investigate the effect of a higher protein diet during lifestyle intervention on anthropometry and metabolic biomarkers in children with overweight and obesity.
METHODS: Children (n:208) were recruited from two multicomponent lifestyle camps. One camp was assigned as the intervention group. In the intervention group, carbohydrates-rich foods at breakfast and two in-between-meals were replaced with protein-containing foods to increase the amount of protein from ~ 10-15 energy percent (E%) per day to ~ 25E% per day. Other components were similar between groups. Anthropometry and biochemical measurements were collected at baseline, 10 weeks (after camp) and 52 weeks.
RESULTS: The intervention group had a non-significant improvement in BMI-SDS (- 0.07 SD (- 0.19; 0.05), p = 0.24) compared to the control group, but in general, there was no effect of a higher protein diet on anthropometry and metabolic biomarkers. Overall, 10 weeks at camp resulted in a more favorable body composition [- 6.50 kg (p < 0.00), - 0.58 BMI-SDS (p < 0.00), and - 5.92% body fat (p < 0.00)], and improved metabolic health, with most changes maintained at 52 weeks.
CONCLUSIONS: A higher protein diet had no significant effect on body composition and metabolic health; however, these lifestyle camps are an efficiatious treatment strategy for childhood obesity.
BACKGROUND: clinicaltrials.gov with ID: NCT04522921. Preregistered August 21st 2020.
METHODS: Children (n:208) were recruited from two multicomponent lifestyle camps. One camp was assigned as the intervention group. In the intervention group, carbohydrates-rich foods at breakfast and two in-between-meals were replaced with protein-containing foods to increase the amount of protein from ~ 10-15 energy percent (E%) per day to ~ 25E% per day. Other components were similar between groups. Anthropometry and biochemical measurements were collected at baseline, 10 weeks (after camp) and 52 weeks.
RESULTS: The intervention group had a non-significant improvement in BMI-SDS (- 0.07 SD (- 0.19; 0.05), p = 0.24) compared to the control group, but in general, there was no effect of a higher protein diet on anthropometry and metabolic biomarkers. Overall, 10 weeks at camp resulted in a more favorable body composition [- 6.50 kg (p < 0.00), - 0.58 BMI-SDS (p < 0.00), and - 5.92% body fat (p < 0.00)], and improved metabolic health, with most changes maintained at 52 weeks.
CONCLUSIONS: A higher protein diet had no significant effect on body composition and metabolic health; however, these lifestyle camps are an efficiatious treatment strategy for childhood obesity.
BACKGROUND: clinicaltrials.gov with ID: NCT04522921. Preregistered August 21st 2020.
摘要：
目标：在成年人中，富含蛋白质的饮食似乎对饱腹感有益，减肥,和体重管理；然而，调查儿童膳食蛋白质和体重发育的研究很少且不一致.这项非随机对照试验旨在研究生活方式干预期间高蛋白饮食对超重和肥胖儿童人体测量和代谢生物标志物的影响。
方法：从两个多组分生活方式营地招募儿童（n：208）。一个营地被分配为干预组。在干预组中，早餐和两餐之间富含碳水化合物的食物被含蛋白质的食物代替，以将蛋白质的含量从每天约10-15能量百分比（E％）增加到每天约25E％。其他成分在组间相似。在基线时收集人体测量学和生化测量，10周（营后）和52周。
结果：干预组BMI-SDS无明显改善（-0.07SD（-0.19;0.05），p=0.24）与对照组相比，但总的来说,高蛋白饮食对人体测量学和代谢生物标志物没有影响.总的来说,在营地10周导致更有利的身体组成[-6.50kg（p<0.00），-0.58BMI-SDS（p<0.00），和-5.92%体脂（p<0.00）]，改善代谢健康，大多数变化维持在52周。
结论：高蛋白饮食对身体成分和代谢健康没有显著影响；然而，这些生活方式营地是儿童肥胖的有效治疗策略。
背景：clinicaltrials.gov，ID：NCT04522921。预注册2020年8月21日。
方法：从两个多组分生活方式营地招募儿童（n：208）。一个营地被分配为干预组。在干预组中，早餐和两餐之间富含碳水化合物的食物被含蛋白质的食物代替，以将蛋白质的含量从每天约10-15能量百分比（E％）增加到每天约25E％。其他成分在组间相似。在基线时收集人体测量学和生化测量，10周（营后）和52周。
结果：干预组BMI-SDS无明显改善（-0.07SD（-0.19;0.05），p=0.24）与对照组相比，但总的来说,高蛋白饮食对人体测量学和代谢生物标志物没有影响.总的来说,在营地10周导致更有利的身体组成[-6.50kg（p<0.00），-0.58BMI-SDS（p<0.00），和-5.92%体脂（p<0.00）]，改善代谢健康，大多数变化维持在52周。
结论：高蛋白饮食对身体成分和代谢健康没有显著影响；然而，这些生活方式营地是儿童肥胖的有效治疗策略。
背景：clinicaltrials.gov，ID：NCT04522921。预注册2020年8月21日。
