Abstract：
Laser sources have established their potential effect in inducing hair regrowth. No large cohort study has evaluated the effect of ablative fractional 2940-nm erbium yttrium aluminum garnet (Er: YAG) laser in the treatment of androgenetic alopecia (AGA). To investigate the efficacy and safety of the ablative fractional 2940-nm Er: YAG laser in combination with medication therapy for the treatment of AGA. We performed a retrospective study between first July 2021 to 30th December 2021. All included patients received oral finasteride and topical minoxidil, or combined with six sessions of Er: YAG laser at 2-week intervals. Patients were divided into medication or combined therapy groups. The efficacy of the two therapies was evaluated by the investigator\'s Global Assessment (IGA) scores and the patient\'s Likert satisfaction scale at week 12 and week 24. Changes in total, terminal and villous hair count, total and terminal hair diameter, and AGA grade were also recorded. Adverse events were evaluated at each follow-up. A total of 192 male patients with AGA were included, including 67 receiving combination treatment, and 125 receiving medication treatment. At week 24, the combination treatment afforded superior outcomes in the IGA score, patient\'s global assessment, total and terminal hair counts, and diameters (all P<0.05). No severe adverse events were reported in both groups. The combined therapy of ablative fractional Er: YAG laser and medication was superior in treating male AGA than single medication therapy without serious adverse effects.
摘要：
激光源已经确立了它们在诱导毛发再生方面的潜在作用。没有大型队列研究评估了烧蚀分数2940nm的铒钇铝石榴石（Er：YAG）激光治疗雄激素性脱发（AGA）的效果。探讨2940nm激光联合药物治疗AGA的疗效和安全性。我们在2021年7月1日至2021年12月30日之间进行了一项回顾性研究。所有纳入的患者均接受口服非那雄胺和外用米诺地尔，或以2周的间隔与六个疗程的Er：YAG激光组合。将患者分为药物治疗组或联合治疗组。在第12周和第24周，通过研究者的全球评估（IGA）评分和患者的Likert满意度量表评估两种疗法的疗效。总的变化,终端和绒毛的头发计数，总毛直径和终毛直径，和AGA等级也被记录。在每次随访时评估不良事件。共纳入192例男性AGA患者，包括接受联合治疗的67人，125人接受药物治疗。在第24周，联合治疗在IGA评分方面提供了更好的结果，患者的全球评估，总毛发计数和终末毛发计数，和直径(均P<0.05)。两组均未发生严重不良事件。消融分数Er：YAG激光联合药物治疗男性AGA优于单一药物治疗，无严重不良反应。
