PDF(Pubmed)
Abstract：
Avoiding fatigue is a long-standing challenge in both healthy and diseased individuals. Establishing objective standard markers of fatigue is essential to evaluate conditions in spatiotemporally different locations and individuals and identify agents to fight against fatigue. Herein, we introduced a novel method for evaluating fatigue using nervous system markers (including dopamine, adrenaline, and noradrenaline), various cytokine levels (such as interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-10, IL-2, IL-5 and IL-17A), and oxidative stress markers (such as diacron-reactive oxygen metabolites [d-ROMs] and biological antioxidant potential [BAP]) in a rat fatigue model. Using this method, the anti-fatigue effects of methyl dihydrojasmonate (MDJ) and linalool, the fragrance/flavor compounds used in various products, were assessed. Our method evaluated the anti-fatigue effects of the aforementioned compounds based on the changes in levels of the nerves system markers, cytokines, and oxidative stress markers. MDJ exerted more potent anti-fatigue effects than linalool. In conclusion, the reported method could serve as a useful tool for fatigue studies and these compounds may act as effective therapeutic agents for abrogating fatigue symptoms.
摘要：
避免疲劳是健康和患病个体的长期挑战。建立客观的疲劳标准标记对于评估时空不同位置和个体的状况以及识别对抗疲劳的试剂至关重要。在这里，我们介绍了一种使用神经系统标记物（包括多巴胺，肾上腺素,和去甲肾上腺素)，各种细胞因子水平(如白细胞介素[IL]-1β，肿瘤坏死因子[TNF]-α，IL-10，IL-2，IL-5和IL-17A），和大鼠疲劳模型中的氧化应激标志物（例如涤纶活性氧代谢产物[d-ROM]和生物抗氧化潜能[BAP]）。使用此方法，二氢茉莉酸甲酯（MDJ）和芳樟醇的抗疲劳作用，各种产品中使用的香料/香料化合物，被评估。我们的方法根据神经系统标志物水平的变化评估了上述化合物的抗疲劳作用。细胞因子,和氧化应激标志物。MDJ比芳樟醇具有更有效的抗疲劳作用。总之,报道的方法可以作为疲劳研究的有用工具，这些化合物可以作为消除疲劳症状的有效治疗剂。
