放化疗诱导的 ACKR2 + 肿瘤细胞驱动 CD8 + T 细胞衰老和宫颈癌复发。
关键词: ACKR2 CD8(+) T cell senescence cervical cancer single-cell RNA sequencing tumor recurrence
Mesh : Humans CD8-Positive T-Lymphocytes / immunology metabolism Female Uterine Cervical Neoplasms / pathology genetics therapy immunology drug therapy Cellular Senescence Chemoradiotherapy / methods Neoplasm Recurrence, Local / pathology genetics Animals Mice Cell Line, Tumor Prognosis Drug Resistance, Neoplasm / genetics Gene Expression Regulation, Neoplastic Transforming Growth Factor beta / metabolism T-Cell Senescence
来 源:
DOI:10.1016/j.xcrm.2024.101550
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