Abstract：
BACKGROUND: Anxiety in Parkinson disease (PD) negatively impacts quality of life. While research predominantly focuses on central nervous system changes, some evidence suggests a connection between peripheral autonomic dysfunctions and PD-related anxiety. The role of the peripheral autonomic nervous system in this context may be overlooked.
OBJECTIVE: This study explores the link between anxiety symptoms and cardiac sympathetic denervation in PD using 11C-meta-hydroxyephedrine ([11C]HED) PET cardiac imaging.
METHODS: We studied 34 non-demented PD subjects, assessing anxiety levels through the Spielberg Anxiety State-Trait test trait section (STAI-T). Patients underwent comprehensive assessments along with [11C]HED cardiac and [11C]DTBZ brain PET. To identify subdimensions of STAI-T, we employed principal components analysis (PCA). We examined associations between the anxiety subdimensions and two measures of cardiac sympathetic denervation from [11C]HED PET. We utilized correlation and linear regression models for these analyses.
RESULTS: PCA revealed two STAI-T results components: anxiety-depressive and pure anxiety subcomponents. Only pure anxiety significantly correlated with measures of cardiac sympathetic denervation (rhos -0.40, p = 0.018; 0.35, p = 0.043). Regression models confirmed a significant association, with cardiac sympathetic denervation explaining ∼20 % of pure anxiety variance, independent of sex, dopaminergic impairment, and anxiolytic treatments.
CONCLUSIONS: This study provides preliminary evidence of peripheral autonomic nervous system abnormalities contributing to PD-related anxiety, suggesting dysregulation in peripheral autonomic functions influencing anxiety perception.
OBJECTIVE: This study explores the link between anxiety symptoms and cardiac sympathetic denervation in PD using 11C-meta-hydroxyephedrine ([11C]HED) PET cardiac imaging.
METHODS: We studied 34 non-demented PD subjects, assessing anxiety levels through the Spielberg Anxiety State-Trait test trait section (STAI-T). Patients underwent comprehensive assessments along with [11C]HED cardiac and [11C]DTBZ brain PET. To identify subdimensions of STAI-T, we employed principal components analysis (PCA). We examined associations between the anxiety subdimensions and two measures of cardiac sympathetic denervation from [11C]HED PET. We utilized correlation and linear regression models for these analyses.
RESULTS: PCA revealed two STAI-T results components: anxiety-depressive and pure anxiety subcomponents. Only pure anxiety significantly correlated with measures of cardiac sympathetic denervation (rhos -0.40, p = 0.018; 0.35, p = 0.043). Regression models confirmed a significant association, with cardiac sympathetic denervation explaining ∼20 % of pure anxiety variance, independent of sex, dopaminergic impairment, and anxiolytic treatments.
CONCLUSIONS: This study provides preliminary evidence of peripheral autonomic nervous system abnormalities contributing to PD-related anxiety, suggesting dysregulation in peripheral autonomic functions influencing anxiety perception.
摘要：
背景：帕金森病（PD）患者的焦虑对生活质量有负面影响。虽然研究主要集中在中枢神经系统的变化，一些证据表明外周自主神经功能障碍与PD相关焦虑之间存在联系.在这种情况下，周围自主神经系统的作用可能会被忽视。
目的：本研究使用11C-间羟基麻黄碱（[11C]HED）PET心脏成像，探讨了PD中焦虑症状与心脏交感神经支配之间的联系。
方法：我们研究了34名非痴呆的PD受试者，通过斯皮尔伯格焦虑状态特征测试特征部分(STAI-T)评估焦虑水平。患者接受全面评估以及[11C]HED心脏和[11C]DTBZ脑PET。要识别STAI-T的子维度，我们采用主成分分析(PCA)。我们从[11C]HEDPET检查了焦虑子维度与心脏交感神经支配的两种测量之间的关联。我们利用相关和线性回归模型进行这些分析。
结果：PCA揭示了两种STAI-T结果成分：焦虑抑郁和纯焦虑子成分。只有纯粹的焦虑与心脏交感神经支配的测量显着相关（ros-0.40，p=0.018；0.35，p=0.043）。回归模型证实了一种显著的关联，心脏交感神经支配解释了20%的纯粹焦虑变异，与性无关,多巴胺能损伤，和抗焦虑治疗。
结论：这项研究提供了外周自主神经系统异常导致PD相关焦虑的初步证据，提示外周自主神经功能失调影响焦虑感知。
目的：本研究使用11C-间羟基麻黄碱（[11C]HED）PET心脏成像，探讨了PD中焦虑症状与心脏交感神经支配之间的联系。
方法：我们研究了34名非痴呆的PD受试者，通过斯皮尔伯格焦虑状态特征测试特征部分(STAI-T)评估焦虑水平。患者接受全面评估以及[11C]HED心脏和[11C]DTBZ脑PET。要识别STAI-T的子维度，我们采用主成分分析(PCA)。我们从[11C]HEDPET检查了焦虑子维度与心脏交感神经支配的两种测量之间的关联。我们利用相关和线性回归模型进行这些分析。
结果：PCA揭示了两种STAI-T结果成分：焦虑抑郁和纯焦虑子成分。只有纯粹的焦虑与心脏交感神经支配的测量显着相关（ros-0.40，p=0.018；0.35，p=0.043）。回归模型证实了一种显著的关联，心脏交感神经支配解释了20%的纯粹焦虑变异，与性无关,多巴胺能损伤，和抗焦虑治疗。
结论：这项研究提供了外周自主神经系统异常导致PD相关焦虑的初步证据，提示外周自主神经功能失调影响焦虑感知。
