PDF(Pubmed)
Abstract：
The identification of immunogenic peptides has become essential in an increasing number of fields in immunology, ranging from tumor immunotherapy to vaccine development. The nature of the adaptive immune response is shaped by the similarity between foreign and self-protein sequences, a concept extensively applied in numerous studies. Can we precisely define the degree of similarity to self? Furthermore, do we accurately define immune self? In the current work, we aim to unravel the conceptual and mechanistic vagueness hindering the assessment of self-similarity. Accordingly, we demonstrate the remarkably low consistency among commonly employed measures and highlight potential avenues for future research.
摘要：
在越来越多的免疫学领域中,免疫原性肽的鉴定已成为必不可少的。从肿瘤免疫疗法到疫苗开发。适应性免疫反应的性质是由外源和自身蛋白序列之间的相似性决定的。在许多研究中广泛应用的概念。我们能准确定义与自我的相似程度吗？此外，我们能准确定义免疫自我吗？在目前的工作中，我们的目标是解开阻碍自相似性评估的概念和机械模糊性。因此，我们证明了常用措施之间的一致性非常低，并强调了未来研究的潜在途径。
