Abstract：
Previous cross-sectional studies suggest that birth weight (BW) is associated with aggression-, social- and attention problems differently in boys and girls. We sought to test if these differences could be confirmed in a longitudinal study. The 1989 Raine Study provided prospectively collected data on perinatal variables and repeated child behaviour checklist assessments from ages 5 to 17. Linear mixed effects models provided crude and adjusted relationships between BW and childhood behaviour at a conservative significance threshold using prenatal maternal covariables in adjusted models. Sensitivity analyses included an age10 teacher assessment. Data on behaviour, BW and sex, was available in 2269 participants. Male sex was associated with increased aggression problems at lower BW compared to females in the crude model (Interaction B: -0.436, 98.3%CI: [-0.844, -0.0253]), but not the adjusted model (Interaction B: -0.310, 98.3%CI: [-0.742, 0.140]). Male sex was associated with increased attention problems at lower BW compared to females in both the crude model (Interaction B: -0.334, 98.3%CI: [-0.530, -0.137]) and the adjusted model (Interaction B: -0.274, 98.3%CI: [-0.507, -0.0432]). Male sex was associated with increased social problems at lower BW compared to females in both the crude model (Interaction B: -0.164, 98.3%CI: [-0.283, -0.0441]) and the adjusted model (Interaction B: -0.148, 98.3%CI: [-0.285, -0.00734]). Using repeated measures from ages 5-17 we were able to show a crude and adjusted male vulnerability to lower BW in the development of attention problems and social problems. We did not find a BW x sex interaction for the development of aggressive behaviour.
摘要：
先前的横断面研究表明，出生体重(BW)与侵袭有关，男孩和女孩的社会和注意力问题不同。我们试图测试这些差异是否可以在纵向研究中得到证实。1989年的Raine研究提供了有关围产期变量的前瞻性收集数据，以及5至17岁儿童的重复行为清单评估。线性混合效应模型使用调整模型中的产前母体协变量，以保守的显著性阈值提供了BW与儿童行为之间的粗略和调整的关系。敏感性分析包括10岁教师评估。行为数据，BW和性别，在2269名参与者中可用。与原始模型中的女性相比，男性在较低体重时与侵略问题增加有关（相互作用B：-0.436，98.3CI：[-0.844，-0.0253]），但不是调整后的模型(相互作用B：-0.310，98.3CI：[-0.742，0.140])。在粗模型（相互作用B：-0.334，98.3CI：[-0.530，-0.137]）和调整后的模型（相互作用B：-0.274，98.3CI：[-0.507，-0.0432]）中，与女性相比，男性在较低体重时的注意力问题增加。在粗模型（交互作用B：-0.164，98.3CI：[-0.283，-0.0441]）和调整后的模型（交互作用B：-0.148，98.3CI：[-0.285，-0.00734]）中，与女性相比，男性在较低体重下的社会问题增加。使用5-17岁的反复措施，我们能够显示出在注意力问题和社会问题的发展中，男性对较低体重的脆弱性。我们没有发现BWx性别相互作用来发展攻击行为。
