PDF(Pubmed)
Abstract：
BACKGROUND: Cluster headache is a severe and debilitating neurological condition characterized by intense, excruciating pain with a significant impact on patients\' wellbeing. Although different treatment options are available, many patients continue to experience inadequate relief. Therefore, experimental strategies are increasingly studied. One of the more promising approaches is the use of ketamine. We present the currently available evidence and our own data.
METHODS: In this mixed-methods paper, we first summarize the available evidence of ketamine for treatment of cluster headache based on a systematic review of literature in MEDLINE, EMBASE and the Cochrane library of systematic reviews. As the level of evidence is quite limited, we report our own cohort study with ten patients treated with ketamine infusions for cluster headache. They were followed up to investigate the patients\' experience of treatment success and quality of life.
RESULTS: The search and review of literature identified four reports with a total of 68 patients. All were uncontrolled case series. The current literature suggests that ketamine might decrease cluster headache. However, as the applied regimes and reported outcomes are highly heterogeneous, further analysis was futile. Our own data show high patient satisfaction with ketamine treatment.
CONCLUSIONS: Despite the limited evidence, ketamine might be considered a potential therapeutic approach for cluster headache. Therefore, further research including randomized controlled trials should be encouraged.
This article discusses the potential use of ketamine for the treatment of cluster headache, a severe neurological condition that can have a significant impact on patients\' quality of life. The authors conducted a systematic review of the existing literature on ketamine for the treatment of cluster headache. Additionally, they also presented their own cohort study of ten patients receiving ketamine infusions. The review of the literature revealed four reports with a total of 68 patients, all of which were uncontrolled case series. While the current literature suggests that ketamine may be effective in relieving cluster headache symptoms, the heterogeneity of treatment regimens and reported outcomes makes it difficult to draw definitive conclusions. The authors\' own cohort study found that patients were very satisfied with ketamine treatment, indicating a potential benefit of this approach. However, due to the limited evidence available, further research, including randomized controlled trials, is needed to better understand the efficacy of ketamine in the treatment of cluster headaches.
METHODS: In this mixed-methods paper, we first summarize the available evidence of ketamine for treatment of cluster headache based on a systematic review of literature in MEDLINE, EMBASE and the Cochrane library of systematic reviews. As the level of evidence is quite limited, we report our own cohort study with ten patients treated with ketamine infusions for cluster headache. They were followed up to investigate the patients\' experience of treatment success and quality of life.
RESULTS: The search and review of literature identified four reports with a total of 68 patients. All were uncontrolled case series. The current literature suggests that ketamine might decrease cluster headache. However, as the applied regimes and reported outcomes are highly heterogeneous, further analysis was futile. Our own data show high patient satisfaction with ketamine treatment.
CONCLUSIONS: Despite the limited evidence, ketamine might be considered a potential therapeutic approach for cluster headache. Therefore, further research including randomized controlled trials should be encouraged.
This article discusses the potential use of ketamine for the treatment of cluster headache, a severe neurological condition that can have a significant impact on patients\' quality of life. The authors conducted a systematic review of the existing literature on ketamine for the treatment of cluster headache. Additionally, they also presented their own cohort study of ten patients receiving ketamine infusions. The review of the literature revealed four reports with a total of 68 patients, all of which were uncontrolled case series. While the current literature suggests that ketamine may be effective in relieving cluster headache symptoms, the heterogeneity of treatment regimens and reported outcomes makes it difficult to draw definitive conclusions. The authors\' own cohort study found that patients were very satisfied with ketamine treatment, indicating a potential benefit of this approach. However, due to the limited evidence available, further research, including randomized controlled trials, is needed to better understand the efficacy of ketamine in the treatment of cluster headaches.
摘要：
背景：丛集性头痛是一种严重且使人衰弱的神经系统疾病，其特征是强烈，痛苦的痛苦，对患者的健康有重大影响。虽然有不同的治疗选择，许多患者继续感到救济不足。因此,实验策略的研究越来越多。更有前途的方法之一是使用氯胺酮。我们提供当前可用的证据和我们自己的数据。
方法：在这篇混合方法论文中，我们首先根据MEDLINE文献的系统综述总结氯胺酮治疗丛集性头痛的现有证据,EMBASE和Cochrane系统评价图书馆。由于证据水平相当有限，我们报告了我们自己的队列研究,该研究纳入了10例接受氯胺酮输注治疗的丛集性头痛患者.对他们进行随访，以了解患者治疗成功的经验和生活质量。
结果：对文献的搜索和回顾确定了4例报告，共68例患者。都是不受控制的病例系列。目前的文献表明氯胺酮可以减少丛集性头痛。然而,由于应用的制度和报告的结果是高度异质的，进一步分析是徒劳的。我们自己的数据显示，患者对氯胺酮治疗的满意度很高。
结论：尽管证据有限，氯胺酮可能被认为是治疗丛集性头痛的潜在方法。因此,应鼓励进一步研究,包括随机对照试验.
本文讨论了氯胺酮治疗丛集性头痛的潜在用途，严重的神经系统疾病，可对患者的生活质量产生重大影响。作者对氯胺酮治疗丛集性头痛的现有文献进行了系统综述。此外,他们还介绍了他们自己对10名接受氯胺酮输注的患者进行的队列研究.文献综述显示4例报告共68例,所有这些都是不受控制的病例系列。虽然目前的文献表明氯胺酮可以有效缓解丛集性头痛症状，治疗方案和报告结局的异质性使得难以得出明确的结论.作者自己的队列研究发现，患者对氯胺酮治疗非常满意，表明这种方法的潜在好处。然而,由于现有的证据有限,进一步研究,包括随机对照试验,需要更好地了解氯胺酮在治疗丛集性头痛中的功效。
方法：在这篇混合方法论文中，我们首先根据MEDLINE文献的系统综述总结氯胺酮治疗丛集性头痛的现有证据,EMBASE和Cochrane系统评价图书馆。由于证据水平相当有限，我们报告了我们自己的队列研究,该研究纳入了10例接受氯胺酮输注治疗的丛集性头痛患者.对他们进行随访，以了解患者治疗成功的经验和生活质量。
结果：对文献的搜索和回顾确定了4例报告，共68例患者。都是不受控制的病例系列。目前的文献表明氯胺酮可以减少丛集性头痛。然而,由于应用的制度和报告的结果是高度异质的，进一步分析是徒劳的。我们自己的数据显示，患者对氯胺酮治疗的满意度很高。
结论：尽管证据有限，氯胺酮可能被认为是治疗丛集性头痛的潜在方法。因此,应鼓励进一步研究,包括随机对照试验.
本文讨论了氯胺酮治疗丛集性头痛的潜在用途，严重的神经系统疾病，可对患者的生活质量产生重大影响。作者对氯胺酮治疗丛集性头痛的现有文献进行了系统综述。此外,他们还介绍了他们自己对10名接受氯胺酮输注的患者进行的队列研究.文献综述显示4例报告共68例,所有这些都是不受控制的病例系列。虽然目前的文献表明氯胺酮可以有效缓解丛集性头痛症状，治疗方案和报告结局的异质性使得难以得出明确的结论.作者自己的队列研究发现，患者对氯胺酮治疗非常满意，表明这种方法的潜在好处。然而,由于现有的证据有限,进一步研究,包括随机对照试验,需要更好地了解氯胺酮在治疗丛集性头痛中的功效。
