Abstract：
In this study, we investigated the role of serum/glucocorticoid-regulated kinase 1 (SGK1) in varicella-zoster virus (VZV) replication. VZV DNA replication and plaque formation were inhibited by SGK1 knockout and treatment with an SGK1 inhibitor. Furthermore, SGK1 inhibition suppressed the increase in cyclin B1 expression induced by VZV infection. These results suggest that VZV infection induces SGK1 activation, which is required for efficient viral proliferation through the expression of cyclin B1. This is the first study to report that SGK1 is involved in the VZV life cycle.
摘要：
在这项研究中,我们研究了血清/糖皮质激素调节激酶1(SGK1)在水痘-带状疱疹病毒(VZV)复制中的作用.通过SGK1敲除和用SGK1抑制剂处理来抑制VZVDNA复制和空斑形成。此外，SGK1抑制抑制了VZV感染诱导的细胞周期蛋白B1表达的增加。这些结果表明，VZV感染诱导SGK1激活，这是通过表达细胞周期蛋白B1进行有效病毒增殖所必需的。这是第一个报告SGK1参与VZV生命周期的研究。
